Laboratory of Neural Differentiation (NEDI)
Last update :
August 2024
Selected publications
Potential contribution of spinal interneurons to the etiopathogenesis of Amyotrophic Lateral Sclerosis
Goffin L., Lemoine D. and Clotman F. (2024)
Frontiers in Neuroscience, 18:1434404 (pdf file)
Lhx4 surpasses its paralog Lhx3 in promoting the differentiation of spinal V2a interneurons
Renaux E., Baudouin C., Marchese D., Clovis Y., Pelosi B., Lee S.-K., Gofflot F., Rezsohazy R. and Clotman F. (2024)
Cellular and Molecular Life Science, 81:286 (pdf file)
Potential Roles of Specific Subclasses of Premotor Interneurons in Spinal Cord Function Recovery after Traumatic Spinal Cord Injury in Adults
Dominguez-Bajo A. and Clotman F. (2024)
Cells, 13(8):652 (pdf file)
Brain-wide mapping of efferent projections of glutamatergic (Onecut3+) neurons in the lateral hypothalamus
Zupancic M., Tretiakov E.O., Mate Z., Erdelyi F., Szabo G., Clotman F., Hökfelt T., Harkany T. and Keimpema E. (2023)
Acta Physiologica, e13973 (Carl Ludwig Award 2022 article from Acta Physiologica) (pdf file)
Generation and characterization of a tamoxifen-inducible Vsx1-CreERT2 line to target V2 interneurons in the mouse developing spinal cord
Baudouin C., Pelosi B. (equal contribution), Courtoy G.E., Achouri Y. and Clotman F. (2021)
Genesis, e23435 (pdf file)
Differentiation and localization of interneurons in the developing spinal cord depends on DOT1L expression
Gray de Cristoforis A., Ferrari F., Clotman F. and Vogel T. (2020)
Molecular Brain, 13(1):85 (pdf file)
Molecular design of hypothalamus development
Romanov RA, Tretiakov EO, Kastriti ME, Zupancic M, Häring M, Korchynska S, Popadin K, Benevento M, Rebernik P, Lallemend F, Nishimori K, Clotman F, Andrews WD, Parnavelas JG, Farlik M, Bock C, Adameyko I, Hökfelt T, Keimpema E, Harkany T. (2020)
Nature, 582(7811):246-252 (pdf file)
Onecut-dependent Nkx6.2 transcription factor expression is required for proper formation and activity of spinal locomotor circuits
Toch M., Harris A., Schakman O., Kondratskaya E., Boulland J.L., Dauguet N., Debrulle S., Baudouin C., Hidalgo-Figueroa M., Mu X., Gow A., Glover J.C., Tissir F. and Clotman F. (2020)
Scientific Reports, 10(1):996 (pdf file)
Vsx1 and Chx10 paralogs sequentially secure V2 interneuron identity during spinal cord development
Debrulle S., Baudouin C., Hidalgo-Figueroa M., Pelosi B., Francius C., Rucchin V., Ronellenfitch K., Chow R.L., Tissir F., Lee S.-K. and Clotman F. (2020)
Cellular and Molecular Life Science, 77(20):4117-4131 (pdf file)
Pou2f2 regulates the distribution of dorsal interneurons in the mouse developing spinal cord
Masgutova G., Harris A., Jacob B., Corcoran L.M. and Clotman F. (2019)
Frontiers in Molecular Neuroscience, 12:263 (pdf file)
CBP and p300 coactivators contribute to the maintenance of Isl1 expression by the Onecut transcription factors in embryonic spinal motor neurons
Toch M. and Clotman F. (2019)
Molecular and Cellular Neuroscience, 101:103411 (pdf file)
Onecut factors and Pou2f2 regulate the distribution of V2 interneurons in the mouse developing spinal cord
Harris A., Masgutova M., Collin A., Toch M., Hidalgo-Figueroa M., Jacob B., Corcoran L.M., Francius C. and Clotman F. (2019)
Frontiers in Cellular Neuroscience, 13: 184 (pdf file)
Guidance of motor axons: Where do we stand ?
Clotman F. and Tissir F. (2018)
Current Opinion in Physiology, 4 pp. 76–81 (pdf file)
The Onecut transcription factors regulate differentiation and distribution of dorsal interneurons during spinal cord development
Kabayiza K., Masgutova G., Harris A., Rucchin V., Jacob B. and Clotman F. (2017)
Frontiers in Molecular Neuroscience, 10:157 (pdf file)
Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes
Romanov RA, Zeisel A, Bakker J, Girach F, Hellysaz A, Tomer R, Alpár A, Mulder J, Clotman F, Keimpema E, Hsueh B, Crow AK, Martens H, Schwindling C, Calvigioni D, Bains JS, Máté Z, Szabó G, Yanagawa Y, Zhang MD, Rendeiro A, Farlik M, Uhlén M, Wulff P, Bock C, Broberger C, Deisseroth K, Hökfelt T, Linnarsson S, Horvath TL, Harkany T. (2017)
Nature Neuroscience, 20(2) pp. 176-188 (pdf file)
Vsx1 transiently defines an early intermediate V2 interneuron precursor compartment in the mouse developing spinal cord.
Francius C., Hidalgo-Figueroa M. (equal contribution), Debrulle S., Pelosi B., Rucchin V., Ronellenfitch K., Panayiotou E., Makrides N., Misra K., Harris A., Hassani H., Schakman O., Parras C., Xiang M., Malas S., Chow R.L. and Clotman F. (2016)
Frontiers in Molecular Neuroscience, 9:145 (pdf file)
Celsr3 is required in motor neurons to steer their axons in the hindlimb.
Chai G., Zhou L., Manto M., Helmbacher F., Clotman F., Goffinet A.M. and Tissir F. (2014)
Nature Neuroscience, 17 (9) pp. 1171-1179 (pdf file and supplemental data)
Generating spinal motor neuron diversity: a long quest for neuronal identity.
Francius C., Clotman F. (2014)
Cellular and Molecular Life Science, 71 pp. 813-829 (pdf file)
Identification of multiple subsets of ventral interneurons and differential distribution along the rostrocaudal axis of the developing spinal cord.
Francius C., Harris A.A., Hendricks T.J., Stam F., Barber M., Kurek D., Grosveld F.G., Pierani A., Goulding M. and Clotman, F. (2013) Cl
PLoS One, 8 (8): e70325 (pdf file)
The Onecut transcription factor HNF-6 regulates in motor neurons the formation of the neuromuscular junctions.
Audouard E., Schakman O., René F., Huettl R.-E., Huber A.B., Loeffler J.-P., Gailly P. and Clotman F. (2012)
PLoS One, 7 (12):e50509 (pdf file)
Onecut transcription factors act upstream of Isl1 to regulate spinal motoneuron diversification.
Roy A., Francius C. (equal contribution), Rousso D.L., Seuntjes E., Debruyn J., Luxenhofer G., Huber A.B., Huylebroeck D., Novitch B.G. and Clotman F. (2012)
Development, 139 (17) pp. 3109-19 (pdf file)
Control of Renshaw cell inhibitory interneuron specialization by a temporally restricted transcription factor program.
Stam F., Hendricks T.J. (equal contribution), Geiman E., Zhang, J., Francius C., Labosky, P., Clotman F. and Goulding M. (2012)
Development, 139 (1) pp. 179-190 (pdf file)
Dynamic expression of the Onecut transcription factors HNF-6, OC-2 and OC-3 during spinal motor neuron development.
Francius, C. and Clotman, F. (2010)
Neuroscience, 165 (1) pp. 116-129 (pdf file)
The full bibliography record of the NEDI lab is available in the DIAL database of UCLouvain.
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Concerted transcriptional regulation of the morphogenesis of hypothalamic neurons
Zupancic M., Keimpema E., Tretiakov E.O., Eder E.J., Lev I., Englmaier L., Bhandari P., Fietz S.A., Härtig W., Renaux E., Villunger A., Hökfelt T., Zimmer M., Clotman F. and Harkany T. (2024)
Nature Communications, in press
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