 Aims
To give to the pharmacists the bases necessary to include/understand the metabolic ways implied in the biotransformation of xénobiotique as well as the factors which can influence this metabolism (genes, age, etc).
Main themes
This course details the principal reactions implied at the time of the metabolism of the xénobiotiques ones. Using composed of reference one analyzes which reactional sites of a molecule are the potential seat for reactions of phase I and phase II In the same way, the aspects biochemical and genetic able to influence this biotransformation (families, subfamilles and isoformes P450, genetic polymorphism, inductors) are discussed.
Content and teaching methods
Three modules are proposed. - (1) reactions of phase I Cytochrome P450 (classification, catalytic cycle, mechanism of action); Oxidation of the Carbon atoms (hydroxylation, epoxydation, dealkylation); Oxidation of heteroatoms (N-oxides, Sulfoxides). - (2) reactions of phase II Mechanisms of reaction and type of substrates. Méthylation, Acetylation, Glucuronoconjugaison, Sulfoconjugaison, Combined in Glutathion and the amino acids. - (3) Pharmacogénétique. Discussion of the factors which influence the metabolism: genetic aspects, sex, race, age, nutriments, drugs, inductors and inhibitors. The teaching method is based in the lecturing. Moreover, one seminar (work completed by group of 2 students) is carried out. They consider the theoretical metabolism of a drug, which is compared with the metabolism described at the man (obtained after library search). A note (20% of the total note of the course) showing the written report/ratio and the oral presentation is allotted.
Other information (prerequisite, evaluation (assessment methods), course materials recommended readings, ...)
Pre-necessary: organic chemistry, general and medical biochemistry, cellular biology. Evaluation: written examination and oral presentation of personal work. Support: transparencies and table, not of syllabus. Framing: 1 PST to frame the seminars. Means: nothing Others: nothing
Programmes in which this activity is taught
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ESP3DS
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Diplôme d'études spécialisées en santé publique
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ESP3DS/ST
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Diplôme d'études spécialisées en santé publique (santé au travail)
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NUT2
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Licence en sciences biomédicales (nutrition humaine)
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Other credits in programs
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ESP3DS/TI
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Diplôme d'études spécialisées en santé publique (santé au travail - toxicologie industrielle)
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Mandatory
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FARM21
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Première année du grade de pharmacien
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(3 credits)
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Mandatory
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SBIM31DS
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Première année du diplôme d'études spécialisées en sciences biomédicales
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(3 credits)
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SBIM32DS/TE
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Deuxième année du diplôme d'études spécialisées en sciences biomédicales (toxicologie expérimentale)
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(3 credits)
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Mandatory
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TOX21
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Première licence en sciences biomédicales (toxicologie)
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(3 credits)
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Mandatory
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