For several years, obesity and associated pathologies have been the focus of attention in public health, given the dramatic consequences for the comfort of living and the societal cost of caring for these patients. In this context, the gut microbiota seems to be an interesting therapeutic target
However, current scientific knowledge does not fully understand how this type of prebiotic can have a beneficial effect on health in the context of obesity and its associated pathologies. Moreover, no study to date has considered the interest of foods naturally rich in fructans for the control of obesity.
The Walloon region in Belgium supports the FOOD4GUT project which proposes a multidisciplinary approach to study societal, behavioral and dietary changes highlighting the impact of the consumption of vegetables rich in locally produced fructans on the eating behavior and metabolic disorders associated with obesity.
The FOOD4GUT project is an innovative approach in nutrition, aiming to prove that an individual and societal behavior change, promoting the intake of locally produced vegetables rich in fructan-type prebiotics, may create a real public health benefit, in agreement with the ecological and economic development of the Walloon Region.
An analytical component will make it possible to map the systems of production and consumption of food sources of fructans and prebiotics grown in Wallonia.
On the other hand, a preclinical experimental approach and a multicenter randomized clinical intervention study (obese population before bariatric surgery) will investigate the fundamental mechanisms by which foods rich in prebiotics can modulate the metabolic disorders, inflammatory process and behavioral changes associated with obesity.
The originality and feasibility of the project is the result of the alliance of recognized scientific experts from fields of expertise in human sciences, biomedical sciences, and technological and agronomic sciences, from the three major university and hospital centers of the Walloon- Brussels.
Click here to see the different academic and industrial partners of the FOOD4GUT project.
1) Towards a more comprehensive concept for prebiotics. Bindels et al. Nat Rev Gastroenterol Hepatol 2015
2) Gut microbiota controls adipose tissue expansion, gut barrier and glucose metabolism: novel insights into molecular targets and interventions using prebiotics. Geurts et al. Benef Microbes 2014
3) Gut microbiota and metabolic disorders: How prebiotic can work? Delzenne et al. Br J Nutr 2013
4) Modulation of the gut microbiota by nutrients with prebiotic properties: consequences for host health in the context of obesity and metabolic syndrome. Delzenne el al. Microb Cell Factor 2011
5) Targeting gut microbiota in obesity: effects of prebiotics and probiotics. Delzenne et al. Nat Rev Endocrinol 2011