PhD defense Archives : Soumillion Laboratory https://sites.uclouvain.be/soumillionlab/tag/phd-defense/ Evolution. Directed. Thu, 27 Jan 2022 19:19:10 +0000 en-US hourly 1 https://wordpress.org/?v=6.3.1 https://sites.uclouvain.be/soumillionlab/wp-content/uploads/2018/10/cropped-Test-1-32x32.png PhD defense Archives : Soumillion Laboratory https://sites.uclouvain.be/soumillionlab/tag/phd-defense/ 32 32 Congratulation to Dr. Gol Mohammad Dorrazehi https://sites.uclouvain.be/soumillionlab/2022/01/18/congratulation-to-dr-gol-mohammad-dorrazehi/ https://sites.uclouvain.be/soumillionlab/2022/01/18/congratulation-to-dr-gol-mohammad-dorrazehi/#comments Tue, 18 Jan 2022 06:29:22 +0000 https://sites.uclouvain.be/soumillionlab/?p=10003 On January 17th, 2022, Dr. Dorrazehi became the newest member of our team to successfully defend his PhD thesis. His thesis title is “The catalytic activity of a DD-peptidase impairs its evolutionary conversion into a  β-lactamase“, which is focused on

L’article Congratulation to Dr. Gol Mohammad Dorrazehi est apparu en premier sur Soumillion Laboratory.

]]> On January 17th, 2022, Dr. Dorrazehi became the newest member of our team to successfully defend his PhD thesis. His thesis title is “The catalytic activity of a DD-peptidase impairs its evolutionary conversion into a  β-lactamase“, which is focused on “challenges in in-vivo directed evolution”, to build on previous works of our laboratory to probe the trade-offs between activity and evolvability of enzymes. In the thesis, he explored intra- and intergenic mechanisms to bypass fitness costs associated with activity of enzymes, e.g. he used the ability of CRISPR/Cas9 for creating genomic libraries to lower the fitness cost. The results of his thesis clearly demonstrate that fitness cost issues are multi-factorial and that an initial careful attention to every biological parameter may be crucial for the success of a directed evolution campaign, especially when dealing with potentially dangerous enzymatic activity such as a hydrolase.

We wish you all the best for the future!

L’article Congratulation to Dr. Gol Mohammad Dorrazehi est apparu en premier sur Soumillion Laboratory.

]]> https://sites.uclouvain.be/soumillionlab/2022/01/18/congratulation-to-dr-gol-mohammad-dorrazehi/feed/ 4 Congratulation to Dr. Jason Baby Chirakadavil https://sites.uclouvain.be/soumillionlab/2021/08/30/congratulation-to-dr-jason-baby-chirakadavil/ https://sites.uclouvain.be/soumillionlab/2021/08/30/congratulation-to-dr-jason-baby-chirakadavil/#respond Mon, 30 Aug 2021 13:10:00 +0000 https://sites.uclouvain.be/soumillionlab/?p=9383 Congratulation to Dr. Jason Chirakadavil! On August the 30th, he successfuly defended in front of a mixed remote and on-site audience. His thesis, “Deep mutational scanning of an alanine racemase from Streptococcus thermophilus” use the natural competence of Streptococcus bacteria

L’article Congratulation to Dr. Jason Baby Chirakadavil est apparu en premier sur Soumillion Laboratory.

]]> Congratulation to Dr. Jason Chirakadavil! On August the 30th, he successfuly defended in front of a mixed remote and on-site audience. His thesis, “Deep mutational scanning of an alanine racemase from Streptococcus thermophilus” use the natural competence of Streptococcus bacteria to more efficiently probe the way enzymes evolve. Jason’s work ethic, supportive attitude and good cheers will be sorely missed. He will continue to explore gene transfer in Gram positive bacteria during a postdoc in the laboratory of Xavier Charpentier à the INSERM in Lyon, France.

L’article Congratulation to Dr. Jason Baby Chirakadavil est apparu en premier sur Soumillion Laboratory.

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