TMEM165 transports calcium and manganese: a new story from Jiri (in JBC)
Jiri functionally characterized human TMEM165 by heterologously expressing it in budding yeast (Saccharomyces cerevisiae) and in the bacterium Lactococcus lactis. He obtained biochemical evidence that TMEM165 mediates calcium and manganese transport. We also used the yeast and bacterial systems to evaluate the impact of four disease-causing missense mutations identified in individuals with TMEM165-associated CDG.