Aims

The objective of this course is to introduce the students to the diversity and mostly the flexibility of genetic systems encountered in microorganisms, wether bacterias or eucaryotes (filamentous fungus or yeast). We go into detail on the different types of organization of genetic information, the modes of genetic regulation (replication and expression), the variations (mutations and rearrangements), reparations and transfers, mostly detailled on bacterias. The genetic systems of inferior eucaryotes presented in depth are nuclear or mendel heredity and cytoplasmic or non-mendel heredity.

Other information (prerequisite, evaluation (assessment methods), course materials recommended readings, ...)

Prerequisites: biochemistry, genetics.
Evaluation: JM- Oral examination preceeded by written preparation. Choice between 2 questions. The aim is to illustrate the diversity of systems encountered. AMC- Article preparation by using genetic tools presented during the course, in the frame of fundamental and applied research. Students may, nevertheless, be questionned on theorical subjects.
Support: reference book: Procaryotic genetic, Joset & Guespin Michel 1994 (JM) and Génétique microbienne, Giraud 1993 (AMC). This last book will probably change since it does not present genetic concepts from experimental examples.

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