Drug design en chimie pharmaceutique

Teacher(s)

Frédérick Raphaël (coordinator); Lambert Didier; Ravez Séverine (compensates Frédérick Raphaël);

Language

French
> English-friendly

Prerequisites

The prerequisite(s) for this Teaching Unit (Unité d’enseignement – UE) for the programmes/courses that offer this Teaching Unit are specified at the end of this sheet.

Main themes

This course offers aimed at deepening the concepts presented in the pharmaceutical chemistry course. The concepts of drug design are discussed through selected examples.

They include:
-       the main pharmacomodulation concepts
-       the rational approaches based on the knowledge of the structure of the target or of the ligands (X-ray, NMR, molecular modeling, pharmacophore approach) incorporating notions seen in the course of biophysics

Learning outcomes

At the end of this learning unit, the student is able to :
1	The course aims at introducing students to the rational design of drugs ("drug design") by means of selected examples either through conventional pharmacochemical modulations or by means of rational approach based on the three-dimensional structure of the target. It also offers an introduction to molecular modeling (molecular dynamics molecular mechanics and semi-quantum methods) and methods of modern drug discovery using the use of bank products (combinatorial chemistry, high throughput screening, .. .).

Faculty or entity

FARM