Metabolic biochemistry

lchm1371  2021-2022  Louvain-la-Neuve

Metabolic biochemistry
5.00 credits
30.0 h + 30.0 h
Q2
Teacher(s)
Page Melissa;
Language
English
Prerequisites

The prerequisite(s) for this Teaching Unit (Unité d’enseignement – UE) for the programmes/courses that offer this Teaching Unit are specified at the end of this sheet.
Main themes
Main themes to cover :
1. Introduction to metabolism
2. Bioenergetics
3. Biochemical transport phenomenon

Main metabolic ways :
1. Glycolysis and hexose catabolism
2. Metabolism of glycogen and glyconeogenesis
3. Oxidation of fatty acids and biosynthesis of lipids
4. Krebs cycle
5. Electron transport, oxidative phosphorylation
6. Metabolism of amino acids, nucleotides and linked molecules.
Main ways of regulation.

The exercises are divided into two complementary parts :
One, followed in the case of CHIM BAC, consists of practical work on a specific question in biochemistry.
The other, for all, consists of preparing, presenting and discussing, in groups, a question linked to a biochemical problem, but voluntarily carrying onto other disciplines of life sciences.
Learning outcomes

At the end of this learning unit, the student is able to :

1 The objective of the theoretical course is to examine the general aspects of glucides, lipids, amino acids and nucleotides metabolism, as well as their regulation.

The course must allow the acquisition and mastering of several types of competences :
General knowledge of metabolism and its regulation modes ;
Comprehension of reactional mechanisms, representation of main metabolic ways, as well as their main regulations ;
Integration of metabolism in the physiology context of cells and organisms, mainly animal.

The goal of exercises is :
Deepening, by practical exercises, basic notions seen in the theoretical course ;
By the realization of a personal interdisciplinary work, based on a problem-situation, integrating the understanding of metabolic biochemistry in the context of life sciences.
 
 
Content
Bioenergetic principles;
Carbohydrate metabolism (glycolysis, fermentation, phosphogluconate pathway, gluconeogenesis and glycogenogenesis);
Krebs cycle and glyoxylate;
Respiratory chain and oxidative phosphorylation;
Photosynthesis;
Oxidation and biosynthesis of lipids;
Urea cycle;
Synthesis and degradation of amino acids and other important nitrogen compounds;
Nucleotide metabolism.
 
Instruction will take place in english.
Teaching methods
The skills targeted by the course will be developed using lectures. 
Laboratory sessions are for chemistry and biology students, and not for students in veterinary science.
Evaluation methods
For all students, evaluation includes :
1. a written exam that will take place during the June exam session. Written exam including questions requiring precise / short answers, theoretical developments or problem solving.
2. group work, the exam type decided each year, but this can include a group presentation, this evaluation will take place during the normal term
For chemistry and biology students :
1. they will also be evaluated on their participation in laboratory sessions, in which a written report is required for the completion of the evaluation.
Online resources
Slideshows are available via the moodle platform
Bibliography
  • Lehninger Principles of biochemistry 7th edition
  • Voet & Voet Biochemistry 4th Edition
Le cours ne fait appel à aucun support particulier qui serait payant et jugé obligatoire. Les manuels ci-dessus sont recommandés (mais pas obligatoires) sur une base facultative pour un apprentissage plus approfondi
Teaching materials
  • Lehninger Principles of biochemistry 7th edition
  • Voet & Voet Biochemistry 4th Edition
Faculty or entity
CHIM


Programmes / formations proposant cette unité d'enseignement (UE)

Title of the programme
Sigle
Credits
Prerequisites
Learning outcomes
Bachelor in Chemistry