Note from June 29, 2020
Although we do not yet know how long the social distancing related to the Covid-19 pandemic will last, and regardless of the changes that had to be made in the evaluation of the June 2020 session in relation to what is provided for in this learning unit description, new learnig unit evaluation methods may still be adopted by the teachers; details of these methods have been - or will be - communicated to the students by the teachers, as soon as possible.
Although we do not yet know how long the social distancing related to the Covid-19 pandemic will last, and regardless of the changes that had to be made in the evaluation of the June 2020 session in relation to what is provided for in this learning unit description, new learnig unit evaluation methods may still be adopted by the teachers; details of these methods have been - or will be - communicated to the students by the teachers, as soon as possible.
3 credits
30.0 h
Q1
Teacher(s)
Leclercq Joëlle (coordinator); Muccioli Giulio;
Language
French
Prerequisites
- Organic chemistry
- Introduction to analytical chemistry, instrumental analysis
Main themes
The main methods and norms used for purity and quality control of drugs (qualitative and quantitative analysis of impurities, assays,') will be explained
Aims
At the end of this learning unit, the student is able to : | |
| 1 |
- Give to the student the appropriate knowledge:
|
The contribution of this Teaching Unit to the development and command of the skills and learning outcomes of the programme(s) can be accessed at the end of this sheet, in the section entitled “Programmes/courses offering this Teaching Unit”.
Content
- Drugs quality control Pharmacopoeia : general aspects
- Purity of drugs and main degradation pathways
- Identification methods (infra red spectroscopy, nuclear magnetic resonance)
- General identification reactions
- Separation methods (liquid-liquid and solid-liquid extractions, liquid, supercritical and gaz chromatographies, electrophoresis).
- Quantification methods and validation of analytical methods
- Introduction to mass spectrometry (MS), coupling of MS with separation methods
- Tests
- General monographs
- Discussion of monographs
- Examples of the main routes of chemical and physical degradation of a drug
Teaching methods
Teaching method: theoretical teaching
Evaluation methods
Evaluation by a written exam and exercises
Teaching materials
- une version des supports présentés est disponible sur moodle
- Pharmacopée Européenne
Faculty or entity
FARM
