Chimie organique 2ème partie (partim)

WFARM1231P  2016-2017  Bruxelles

Chimie organique 2ème partie (partim)
6.0 credits
45.0 h + 60.0 h
2q

Teacher(s)
Language
Français
Prerequisites

Sufficient knowledge of French. (ii) Having a good knowledge of general and organic chemistry applied to drugs :

WMD1105 chimie générale et minérale

WMD1106 chimie organique

WFAR1004 chimie organique appliquée aux médicaments

Main themes

(i) The course shows how organic synthesis gives access to members of therapeutic families related by a similarity of structure (e.g. benzodiazepins, tricyclic aromatics, dihydropyridines, fluoroquinolones, b-lactam antibiotics, b-blocking agents, steroïds...). (ii) Two topics not covered in MD1004 and FARM1004 are also briefly presented : heterocyclic chemistry and polymers.

Aims

This course is mainly devoted to the industrial synthesis of drugs, taking the retrosynthetic point of view : given a drug structure, how could it be synthesized from simple industrial precursors ? Practicals give the opportunity to master the methods of organic chemistry in the laboratory.

The contribution of this Teaching Unit to the development and command of the skills and learning outcomes of the programme(s) can be accessed at the end of this sheet, in the section entitled “Programmes/courses offering this Teaching Unit”.

Evaluation methods

Evaluation : written examination measuring problem solving capabilities.

Content

The lessons and tutoring activities are aimed to render the students familiar with the main reactions described in the patent literature on active principles (Axel Kleemann and Jürgen Engel, Pharmaceutical Substances, Syntheses, Patents, Applications, Thieme, Stuttgard, New York). The emphasis is on the retrosynthetic approach applied to the medicinal specialities of the belgian market.

Faculty or entity<


Programmes / formations proposant cette unité d'enseignement (UE)

Program title
Sigle
Credits
Prerequisites
Aims
Minor in Medication Sciences (SBIM students)
6
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