{"id":10003,"date":"2022-01-18T07:29:22","date_gmt":"2022-01-18T06:29:22","guid":{"rendered":"https:\/\/sites.uclouvain.be\/soumillionlab\/?p=10003"},"modified":"2022-01-27T20:19:10","modified_gmt":"2022-01-27T19:19:10","slug":"congratulation-to-dr-gol-mohammad-dorrazehi","status":"publish","type":"post","link":"https:\/\/sites.uclouvain.be\/soumillionlab\/2022\/01\/18\/congratulation-to-dr-gol-mohammad-dorrazehi\/","title":{"rendered":"Congratulation to Dr. Gol Mohammad Dorrazehi"},"content":{"rendered":"\n

On January 17th, 2022, Dr. Dorrazehi became the newest member of our team to successfully defend his PhD thesis. His thesis title is “The catalytic activity of a DD-peptidase impairs its evolutionary conversion into a \u00a0\u03b2-lactamase<\/em>“, which is focused on “challenges in in-vivo directed evolution”, to build on previous works of our laboratory to probe the trade-offs between activity and evolvability of enzymes. In the thesis, he explored intra- and intergenic mechanisms to bypass fitness costs associated with activity of enzymes, e.g. he used the ability of CRISPR\/Cas9 for creating genomic libraries<\/a> to lower the fitness cost. The results of his thesis clearly demonstrate that fitness cost issues are multi-factorial and that an initial careful attention to every biological parameter may be crucial for the success of a directed evolution campaign, especially when dealing with potentially dangerous enzymatic activity such as a hydrolase.<\/p>\n\n\n\n

We wish you all the best for the future!<\/p>\n","protected":false},"excerpt":{"rendered":"

On January 17th, 2022, Dr. Dorrazehi became the newest member of our team to successfully defend his PhD thesis. His thesis title is “The catalytic activity of a DD-peptidase impairs its evolutionary conversion into a \u00a0\u03b2-lactamase“, which is focused on<\/p>\n","protected":false},"author":13,"featured_media":9873,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[53,43,33],"class_list":["post-10003","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-alumni","tag-news","tag-phd-defense"],"yoast_head":"\nCongratulation to Dr. Gol Mohammad Dorrazehi : Soumillion Laboratory<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.uclouvain.be\/soumillionlab\/2022\/01\/18\/congratulation-to-dr-gol-mohammad-dorrazehi\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Congratulation to Dr. Gol Mohammad Dorrazehi : Soumillion Laboratory\" \/>\n<meta property=\"og:description\" content=\"On January 17th, 2022, Dr. Dorrazehi became the newest member of our team to successfully defend his PhD thesis. 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