{"id":10733,"date":"2022-06-07T13:58:25","date_gmt":"2022-06-07T11:58:25","guid":{"rendered":"https:\/\/sites.uclouvain.be\/soumillionlab\/?page_id=10733"},"modified":"2022-06-07T14:38:47","modified_gmt":"2022-06-07T12:38:47","slug":"alessandro-ratto","status":"publish","type":"page","link":"https:\/\/sites.uclouvain.be\/soumillionlab\/staff\/alessandro-ratto\/","title":{"rendered":"Alessandro Ratto"},"content":{"rendered":"\n
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alessandro.ratto{a}uclouvain.be
https:\/\/twitter.com\/lilissandro<\/a> <\/p>\n<\/div>\n\n\n\n

Alessandro RATTO<\/h1>\n\n\n\n

<\/p>\n\n\n\n

BIO<\/strong><\/p>\n\n\n\n

I was born and raised in Turin, Italy, where I got a Bachelor\u2019s degree in Chemistry and a Master\u2019s degree in Industrial Biotechnology, two disciplines that mutually benefit each other when mixed. During an undergraduate Erasmus exchange at Universidad de La Laguna, Spain, I fell in love with Biochemistry and Protein Engineering, a passion that would later ensue in a thesis on the molecular mechanism of the first oxygen-resistant [FeFe]-hydrogenase ever discovered. That research experience, combined with an innate curiosity and an international mindset, would ultimately lead me to Belgium, where I\u2019m now pursuing a PhD in Molecular Biology & Genetic Engineering.<\/p>\n\n\n\n

PROJECT<\/strong><\/p>\n\n\n\n

My PhD project falls under the EU Marie Curie Innovative Training Network (ITN) \u201cEVOdrops\u201d, an international, cross-institute effort focused on pushing the envelope of directed evolution + droplet-based microfluidics. These and other recent Nobel prize-winning technologies are progressively enabling scientists to treat DNA as a programming language \u2013 much like Python or C++ \u2013 to code for specific functions, in a way similar to that of digital apps. Unfortunately, the biotechnological heaven ushered in by a \u201cprogrammable biocatalysis\u201d and synthetic biology is still far away, whereas the methodologies available today are still imperfect and labour-intensive. Hence, my research focuses on making the enzyme directed evolution workflow easier, especially when it is carried out in droplet-based microfluidic setups which have the highest throughput. In particular, I design genetic “software” and \u201cinstall\u201d it in Gram+\/- bacteria via genome editing techniques (such as CRISPR) in order to create host strains that externalize enzymes of interest and can therefore be used as \u201clysis-free\u201d cellular platforms for protein expression and screening.<\/p>\n\n\n\n

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