{"id":10253,"date":"2022-02-03T17:00:50","date_gmt":"2022-02-03T16:00:50","guid":{"rendered":"https:\/\/sites.uclouvain.be\/soumillionlab\/?page_id=10253"},"modified":"2022-02-08T22:54:02","modified_gmt":"2022-02-08T21:54:02","slug":"emiliano-david-primo","status":"publish","type":"page","link":"https:\/\/sites.uclouvain.be\/soumillionlab\/staff\/emiliano-david-primo\/","title":{"rendered":"Emiliano David Primo"},"content":{"rendered":"\n<div class=\"wp-block-image\"><figure class=\"alignleft size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/sites.uclouvain.be\/soumillionlab\/wp-content\/uploads\/2022\/02\/Emi2-1-920x1024.jpg\" alt=\"\" class=\"wp-image-10373\" width=\"380\" height=\"424\" srcset=\"https:\/\/sites.uclouvain.be\/soumillionlab\/wp-content\/uploads\/2022\/02\/Emi2-1-920x1024.jpg 920w, https:\/\/sites.uclouvain.be\/soumillionlab\/wp-content\/uploads\/2022\/02\/Emi2-1-270x300.jpg 270w, https:\/\/sites.uclouvain.be\/soumillionlab\/wp-content\/uploads\/2022\/02\/Emi2-1-768x855.jpg 768w, https:\/\/sites.uclouvain.be\/soumillionlab\/wp-content\/uploads\/2022\/02\/Emi2-1-1380x1536.jpg 1380w, https:\/\/sites.uclouvain.be\/soumillionlab\/wp-content\/uploads\/2022\/02\/Emi2-1-1840x2048.jpg 1840w\" sizes=\"auto, (max-width: 380px) 100vw, 380px\" \/><\/figure><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"has-text-align-right wp-block-paragraph\">Contact<\/p>\n\n\n\n<p class=\"has-text-align-right wp-block-paragraph\">Croix du sud 4-5\/L7.07.06\n<br> Carnoy b.222\n<br>1348 Louvain-la-Neuve<\/p>\n\n\n\n<p class=\"has-text-align-right wp-block-paragraph\">&nbsp;<a href=\"mailto:sebastian.worms@uclouvain.be\">emiliano.primo@uclouvain.be<\/a><\/p>\n\n\n\n<p style=\"text-align:right\"><a itemprop=\"sameAs\" content=\"https:\/\/orcid.org\/0000-0003-3884-8157\" href=\"https:\/\/orcid.org\/0000-0003-3884-8157\" target=\"orcid.widget\" rel=\"noopener noreferrer\" style=\"vertical-align:top;\"><img decoding=\"async\" src=\"https:\/\/orcid.org\/sites\/default\/files\/images\/orcid_16x16.png\" style=\"width:1em;margin-right:.5em;\" alt=\"ORCID iD icon\">orcid.org\/0000-0003-3884-8157<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Emiliano was born and grew up in Argentina. He is a microbiologist and has a PhD in Biological Sciences from the National University of R\u00edo Cuarto (UNRC), Argentina. His doctoral thesis focused on the&nbsp;metabolism of choline (a quaternary ammonium compound) and the enzyme <em>Phosphorylcholine phosphatase,<\/em> and their relationship with the pathogenesis caused by<em> Pseudomonas syringae.&nbsp;<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">He then spent two years working as a postdoctoral researcher at the INBIAS Institute (CONICET-UNRC) in Argentina, researching the role of bacterial surface molecules in rhizobia-legume symbiosis. He looked into the involvement of exopolysaccharides (EPS) and proteins in plant-microorganism and microorganism-microorganism interactions through microbiological and physiological methods, and he performed <em>in-silico<\/em> studies to describe the physiological protein-ligands interaction.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">He has considerable experience in the areas of molecular biology, microbiology, and computational biology.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Since December 2020, he has been part of Dr. Soumillion\u2019s laboratory as a postdoctoral researcher.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"research\">Research<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Inteins are well-known protein domains inserted into host proteins. They catalyze their own splicing while ligating the flanking sequences by a new peptide bond. They belong to the HINT superfamily, which also comprises the bacterial-intein-like (BIL) family, whose members have been much less studied. The project carried out by Dr. Emiliano Primo aims to characterize the autocatalytic mechanism of an extracellular bacterial-intein-like (BIL) domain embedded in large extracellular proteins from <em>Pseudomonas syringae<\/em> pv. <em>tomato<\/em> DC3000. Previously, Dr. P. Soumillion\u2019s team studied this BIL domain and discovered that although it is not capable of splicing, it undergoes efficient self-excision from its host protein while cleaving two peptide bonds at its N- and C-junctions. Interestingly, instead of being ligated through a peptide bond, the flanking polypeptides end up connected by a disulfide bridge.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The project will study this autocatalytic mechanism by combining biochemical and structural biology approaches, and by taking advantage of specific variants whose cleavage at either junction can be chemically triggered.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This BIL domain acts as a maturation domain and may find useful applications in biotechnology or synthetic biology, for the design of autocleavable linkers or modules for conditional protein inactivation, for example.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Contact Croix du sud 4-5\/L7.07.06 Carnoy b.222 1348 Louvain-la-Neuve &nbsp;emiliano.primo@uclouvain.be orcid.org\/0000-0003-3884-8157 Emiliano was born and grew up in Argentina. He is a microbiologist and has a PhD in Biological Sciences from the National University of R\u00edo Cuarto (UNRC), Argentina. His<\/p>\n","protected":false},"author":143,"featured_media":893,"parent":123,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-10253","page","type-page","status-publish","has-post-thumbnail","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Emiliano David Primo : Soumillion Laboratory<\/title>\n<meta name=\"description\" content=\"Intein, Emiliano Primo, autocatalytic, Pseudomonas syringae, structural biology, autocleavable linkers, protein splicing %\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sites.uclouvain.be\/soumillionlab\/staff\/emiliano-david-primo\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Emiliano David Primo : Soumillion Laboratory\" \/>\n<meta property=\"og:description\" content=\"Intein, Emiliano Primo, autocatalytic, Pseudomonas syringae, structural biology, autocleavable linkers, protein splicing %\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sites.uclouvain.be\/soumillionlab\/staff\/emiliano-david-primo\/\" \/>\n<meta property=\"og:site_name\" content=\"Soumillion Laboratory\" \/>\n<meta property=\"article:modified_time\" content=\"2022-02-08T21:54:02+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/sites.uclouvain.be\/soumillionlab\/wp-content\/uploads\/2018\/10\/science_avatar.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"960\" \/>\n\t<meta property=\"og:image:height\" content=\"960\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/sites.uclouvain.be\\\/soumillionlab\\\/staff\\\/emiliano-david-primo\\\/\",\"url\":\"https:\\\/\\\/sites.uclouvain.be\\\/soumillionlab\\\/staff\\\/emiliano-david-primo\\\/\",\"name\":\"Emiliano David Primo : Soumillion Laboratory\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/sites.uclouvain.be\\\/soumillionlab\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/sites.uclouvain.be\\\/soumillionlab\\\/staff\\\/emiliano-david-primo\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/sites.uclouvain.be\\\/soumillionlab\\\/staff\\\/emiliano-david-primo\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/sites.uclouvain.be\\\/soumillionlab\\\/wp-content\\\/uploads\\\/2018\\\/10\\\/science_avatar.jpg\",\"datePublished\":\"2022-02-03T16:00:50+00:00\",\"dateModified\":\"2022-02-08T21:54:02+00:00\",\"description\":\"Intein, Emiliano Primo, autocatalytic, Pseudomonas syringae, structural biology, autocleavable linkers, protein splicing %\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/sites.uclouvain.be\\\/soumillionlab\\\/staff\\\/emiliano-david-primo\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/sites.uclouvain.be\\\/soumillionlab\\\/staff\\\/emiliano-david-primo\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/sites.uclouvain.be\\\/soumillionlab\\\/staff\\\/emiliano-david-primo\\\/#primaryimage\",\"url\":\"https:\\\/\\\/sites.uclouvain.be\\\/soumillionlab\\\/wp-content\\\/uploads\\\/2018\\\/10\\\/science_avatar.jpg\",\"contentUrl\":\"https:\\\/\\\/sites.uclouvain.be\\\/soumillionlab\\\/wp-content\\\/uploads\\\/2018\\\/10\\\/science_avatar.jpg\",\"width\":960,\"height\":960,\"caption\":\"A picture of sebastian worms in a labcoat, doing scinece\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/sites.uclouvain.be\\\/soumillionlab\\\/staff\\\/emiliano-david-primo\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\\\/\\\/sites.uclouvain.be\\\/soumillionlab\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Team\",\"item\":\"https:\\\/\\\/sites.uclouvain.be\\\/soumillionlab\\\/staff\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Emiliano David Primo\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/sites.uclouvain.be\\\/soumillionlab\\\/#website\",\"url\":\"https:\\\/\\\/sites.uclouvain.be\\\/soumillionlab\\\/\",\"name\":\"Soumillion Laboratory\",\"description\":\"Evolution. 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