Université Catholique de Louvain (UCL-Bruxelles)
Programme des Séminaires et Conférences du
Louvain Drug Research Institute et de l'Ecole doctorale en sciences pharmaceutiques
Année académique 2012-2013

publications en relation avec l'exposé:

• Bindels LB*, Dewulf EM*, Delzenne NM. GPR43/FFA2: physio-pathological relevance and therapeutic prospects, accepted in Trends Pharmacol Sci, 2013. (*equally contributed to this work)
• Dewulf et al. Evaluation of the relationship between GPR43 and adiposity in human. Nutr Metab(Lond). (2013) 10:11
• Dewulf et al. Insight into the prebiotic concept: lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women. Gut. 2012 Nov 7. [Epub ahead of print]
• Dewulf et al. Inulin-type fructans with prebiotic properties counteract GPR43 overexpression and PPARgamma-related adipogenesis in the white adipose tissue of high-fat diet-fed mice. J. Nutr Biochem. (2011) 22:712-22
  

Promoteur : N. Delzenne 02.764.73.67 <nathalie.delzenne@uclouvain.be>

Prof. Luc Bertrand
Pole of cardiovascular research
Institute of Clinical and Experimental Research (IREC)

Dip in the heart of cardiac metabolism and function: AMPK, a putative therapeutic target to treat cardiac insulin resistance, hypertrophy and heart failure

publications en relation avec l'exposé:

• Beauloye et al. AMPK activation, a preventive therapeutic target in the transition from cardiac injury to heart failure. Cardiovasc Res. (2011) 90:224-33
• Horman et al. AMP-activated protein kinase in the control of cardiac metabolism and remodeling. Curr Heart Fail Rep. (2012) 9:164-73.
• Steinbusch et al. Overexpession of AMP-activated protein kinase or protein kinase D prevents lipid-induced insulin resistance in cardiomyocytes. J Mol Cell Cardiol. (2013) 55:165-73.

info :P. Cani 02.764.73.97 <patrice.cani@uclouvain.be>

Prof. Jeroen Raes,
Bioinformatics and (eco-)systems biology; Department of Structural Biology;
VIB - Vrije Universiteit Brussel

Monitoring the gut microbiome in health and disease

publications en relation avec l'exposé:

• Faust K, Raes J. Microbial interactions: from networks to models. Nat Rev Microbiol. 2012 Jul 16;10(8):538-50. doi: 10.1038/nrmicro2832. Review.
• Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature. 2012 Jun 13;486(7402):207-14.
• Arumugam M, Raes J, et al Enterotypes of the human gut microbiome. Nature. 2011 May 12;473(7346):174-80.

info :P. Cani 02.764.73.97 <patrice.cani@uclouvain.be>

Prof. Sabine Szunerits
Interdisciplinary Research Institute, Université de Lille I, France

Diamond nanoparticles and other nanomaterials: new jewels for chemistry, biology and medicine

publications en relation avec l'exposé:

• Barras et al. Glycan-functionalized diamond nanoparticles as potent E. coli anti-adhesives. Nanoscale. 2013 Feb 28;5(6):2307-16
• Coffinier et al. Diamond nanowires for highly sensitive matrix-free mass spectrometry analysis of small molecules. Nanoscale. 2012 Jan 7;4(1):231-8.
• Barras et al. Direct functionalization of nanodiamond particles using dopamine derivatives. Langmuir. 2011 Oct 18;27(20):12451-7

info : V. Préat 02.764.73.09 <veronique.preat@uclouvain.be>

Dr. Yuri Dancik,
The Procter & Gamble Company, Brussels

The role of blood, lymphatic and interstitial flow in drug transport to deep tissues after topical application

info : R. Verbeeck 02.764.73.53 <roger.verbeeck@uclouvain.be>

Prof. P. Monteyne,
Vice-president Research & Development Sanofi FRANCE, Paris, France

Évolution de la recherche et développement dans l'industrie pharmaceutique, un modèle en pleine mutation

info :E. Hermans 02.764.93.39 <emmanuel.hermans@uclouvain.be>

publications en relation avec l'exposé:

• Fernandes et al. Nicotinamide enhances apoptosis of G(M)-CSF-treated neutrophils and attenuates endotoxin-induced airway inflammation in mice. Am. J. Phys. Lung Cell Mol Phys 300 : L354-L361, 2011.
• Fernandes et al. Sirtuin inhibition attenuates the production of inflammatory cytokines in lipopolysaccharide-stimulated macrophages. Biochem. Biophys. Res. Com. 420 (4) : 857-861, 2012.
• Fernandes and Vanbever. Preclinical models of pulmonary drug delivery (invited review). Exp. Opin. Drug Deliv. 6 (11) : 1231-1245, 2009. Erratum in Exp. Opin. Drug Deliv. 7 (7) :887-8, 2010.
  

Promoteur :R. Vanbever 02.764.73.25<rita.vanbever@uclouvain.be>

Biological investigations of Vietnamese Euphorbiaceae
Prof. J. Leclercq-Quetin (UCL-CHAM)
C hromatographic fingerprints of herbal extracts as tools for identification or quality control
Dr. G. Alaerts (VUB-FABI)
Data handling of chromatographic herbal fingerprints
Dr. B. Dejaegher (VUB-FABI)

15h30

Application of NMR to plant fingerprinting and metabolomics
Prof. M. Frédérich (ULg)
Title to be announced
Y. Dierckxsens (Tilman)

Prof M. Yoshida,
Division of Metabolomics Research, Division of Gastroenterology, The Integrated Center for Mass Spectrometry, Kobe University Graduate School of Medicine, Japan

Serum metabolomics by GC/MS as a novel diagnostic approach for diseases

publications en relation avec l'exposé:

• Nishiumi S, et al. Serum metabolomics as a novel diagnostic approach for pancreatic cancer. Metabolomics. 2010 Nov;6(4):518-28.
• Yoshie T, et al. Regulation of the metabolite profile by an APC gene mutation in colorectal cancer. Cancer Sci. 2012 Jun;103(6):1010-21
• Sakai A, et al. Metabolomic analysis to discover candidate therapeutic agents against acute pancreatitis. Arch Biochem Biophys. 2012 Jun 15;522(2):107-20
  

info : Claire de Burbure 02.764.52.26 <claire.deburbure@uclouvain.be>

15h45: clinical applications

Resistance: an update on Belgian and European data
Prof. O. Denis, Laboratoire de Référence MRSA-Staphylocoque, ULB
How to vanquish S. aureus in 2012
Prof. S. Vandecasteele, Nephrology and Infectious diseases, AZ St Jan, Brugge
Treating S. aureus infections: from guideline to practice
Dr F. Frippiat, Internal Medicine, CHU Sart Tilman, Liège
Therapeutic options: what’s new in the pipeline ?
Prof. P. Tulkens, Pharmacologie cellulaire et moléculaire, UCL

Further information: see the website of the meeting : http://www.facm.ucl.ac.be/MRSA/

Géraldine de Preter,
Biomedical Magnetic Resonance Unit, LDRI

Florence Colliez,
Biomedical Magnetic Resonance, LDRI

publications en relation avec l'exposé:

• Kapanda et al. Synthesis and Pharmacological Evaluation of 2,4-Dinitroaryldithiocarbamate Derivatives as Novel Monoacylglycerol Lipase Inhibitors. J. Med. Chem. 2012, 55, 5774-5783.
• Kapanda et al . Bis(dialkylaminethiocarbonyl)disulfides as Potent and Selective Monoglyceride Lipase Inhibitors.
  J. Med. Chem. 2009, 52, 7310­7314.
• Kapanda et al. Search for monoglyceride lipase inhibitors: synthesis and screening of
  arylthioamides derivatives.Med Chem Res (2009) 18:243­254.
  

Promoteurs :D. Lambert & J. Poupaert <didier.lambert@uclouvain.be>

Friday , 14 h
Friday, 16h30

Saturday, 9h
Saturday, 11h

Session 1 : Role of ABC transporters in physiology
Session 2: Role of ABC transporters in pathology

Session 3: ABC transporters: structure and mechanisms
Session 4: ABC transporters in non mammalian cells

Full program, registration, abstract submission: see the website of the meeting : http://www.facm.ucl.ac.be/ABC/

Julian Leprince
Centre de Recherche CRIBIO, UCL

Dental restoration and regeneration: a partnership between material science and stem cell biology.

publications en relation avec l'exposé:

• Leprince JG, Zeitlin BD, Tolar M, Peters OA (2012). Interactions between immune system and mesenchymal stem cells in dental pulp and periapical tissues. International Endodontic Journal 45(8):689-701.
• Lamblin G, Leprince JG, Devaux J, Mestdagh M, Gallez B, Leloup G (2010). Hydroxyl radical release from dental resins: Electron paramagnetic resonance evidence. Acta Biomaterialia 6:3193-8.
• Leprince JG, Hadis M, Shortall AC, Ferracane JL, Devaux J, Leloup G, Palin WM (2011). Photoinitiator type and applicability of exposure reciprocity law in filled and unfilled photoactive resins. Dental Materials; 27:157-64.

info : M.P. Mingeot-Leclercq 02.764.73.74 <marie-paule.mingeot@uclouvain.be>

Damien Jacobs & Maxime Taquet
Pharmaceutics, LDRI

Exploring the Central Nervous System and Brain Network with Neuro-Imaging

publications en relation avec l'exposé:

• Bullmore and Sporns. Complex brain networks: graph theoretical analysis of structural and functional systems. Nature, 2009, 10(3):186-98
• Ellingson et al. Diffusion Tensor MR Imaging in Chronic Spinal Cord Injury. American Journal of Neuroradiology, 2008, 29(10):1976-82

info : V. Préat 02.764.73.09 <veronique.preat@uclouvain.be>

Raphaël Robiette
Molecules, Solids and Reactivity, IMCN

Discovery of 5-aryl-1H-imidazoles exhibiting antitumor activity in cancer cells that display resistance to proapoptotic stimuli

• Van Den Berge et al. Planar Chirality of Imidazole-Containing Macrocycles - Understanding and Tuning Atropisomerism. Eur. J. Org. Chem. 2011, 6649-6655.
• Nshimyumukiza et al. Synthesis and Biological Evaluation of Novel Imidazole-Containing Macrocycles. Tetrahedron 2010, 66, 4515-4520.
  

info : M.P. Mingeot-Leclercq 02.764.73.74 <marie-paule.mingeot@uclouvain.be>

publications en relation avec l'exposé:

• Garcia et al. Pharmacodynamic evaluation of the activity of antibiotics against hemin- and menadione-dependent small-colony variants of Staphylococcus aureus in models of extracellular (broth) and intracellular (THP-1 monocytes) infections. Antimicrobial Agents and Chemotherapy (2012) 56:3700-3711
• Garcia et al. Influence of the Protein Kinase C Activator, Phorbol Myristate Acetate (PMA), on the intracellular activity of antibiotics against hemin and menadione auxotrophic Small-Colony Variant (SCV) mutants of Staphylococcus aureus and their wild-type parental strain in human THP-1 cells.Antimicrobial Agents and Chemotherapy (2012) [Epub ahead of print] PMID: 22985883
• Garcia et al. Intracellular forms of menadione-dependent small-colony variants of methicillin-resistant Staphylococcus aureus are hypersusceptible to beta-lactams in a THP-1 cell model due to cooperation between vacuolar acidic pH and oxidant species.J Antimicrob Chemother. 2012 Sep 21. [Epub ahead of print] PMID: 23002174
  

Promoteur : F. Van Bambeke <francoise.vanbambeke@uclouvain.be>

publications en relation avec l'exposé:

• Godechal et al. Assessment of melanoma extent and melanoma metastases invasion using Electron Paramagnetic Resonance and bioluminescence imaging. Contrast Media Molecular Imaging 2011, 6, 282-288
• Godechal and Gallez. The contribution of Electron Paramagnetic Resonance (EPR) to melanoma research. J. Skin Cancer 2011, doi:10.1155/2011/273280 6 pages
• Godechal et al. Optimization of EPR imaging for visualization of human skin melanoma in various stages of invasion. Exp. Dermatol. 2012, 21, 341-346.
• Godechal et al. Electron paramagnetic resonance spectrometry and imaging in melanomas. A comparison between pigmented and non-pigmented human malignant melanomas. Mol. Imaging 2012, in press

Promoteur : B. Gallez <bernard.gallez@uclouvain.be>

Présentation des sujets de thèse des nouveaux inscrits à l'école doctorale (1ère série)

• Lucy Catteau (GNOS) : Recherche de nouvelles molécules d’origine naturelle ayant des propriétés antimicrobiennes ou inversant la résistance aux antibiotiques.
• Pauline De Berdt (FARG): Influence des cellules souches dentaires sur la régénération de la moelle épinière.
• Barbara Dhooghe (LTAP): Développement et validation de nouvelles stratégies en vue d'un traitement curatif de la mucoviscidose.
• Owein Guillemot-Legris (BPBL): Contribution à l'étude du lien entre inflammation périphérique et neuroinflammation dans le cadre du syndrome métabolique.
• Vanessa Jully (FARG): Development of a High-Throughput Screening Platform for the Formulation of Alum Adjuvanted Vaccines.
• Valentin Mutemberzi (BPBL): Mise au point de méthodes de dosage des oxystérols et des métabolites des oxystérols: vers une meilleure compréhension de leur rôle dans l'inflammation.

info: G. Muccioli 02.764.72.31 <giulio.muccioli@uclouvain.be>

Bénédicte Jordan
Biomedical Magnetic Resonance, LDRI

Study of early magnetic resonance markers of tumor response to targeted therapies

publications en relation avec l'exposé:

• Jordan BF, Gallez B. Surrogate MR markers of response to chemo- or radiotherapy in association with co-treatments: a retrospective analysis of multi-modal studies. Contrast Media Mol Imaging. 2010;5(6):323-32.
• Karroum O, et al. Tumor reoxygenation following administration of Mitogen-Activated Protein Kinase inhibitors: A rationale for combination with radiation therapy. Radiother Oncol. 2012. epub.
• Mignion L et al. Use of hyperpolarized 13C-MRS to monitor tumor response to Sorafenib treatment, in comparison with DW-MRI. TOPIM 2013 proceedings
  

iinfo : M.P. Mingeot-Leclercq 02.764.73.74 <marie-paule.mingeot@uclouvain.be>

Jiri Pospisil
Molecules, Solids and Reactivity, IMCN

De l’interface entre chimie physique et la chimie organique à la synthèse de composés biologiquement actifs

publications en relation avec l'exposé:

• De Dobbeleer et al., Unexpected nucleophilic behaviour of free-radicals generated from alpha-iodoketones. Chem. Commun. 2009, 2142-44.
• Pospísil, Markó. Total synthesis of jerangolid. J. Am. Chem. Soc. 2007, 129, 3516-7.
• Nagano et al. Total synthesis and biological evaluation of the cytotoxic resin glycosides ipomoeassin A-F and analogues. Chemistry. 2009, 15, 9697 -9706.

iinfo : M.P. Mingeot-Leclercq 02.764.73.74 <marie-paule.mingeot@uclouvain.be>

Dr Julien Buyck
Pharmacologie cellulaire et moléculaire, LDRI

Pseudomonas aeruginosa: stratégies de résistance aux antibiotiques

publications en relation avec l'exposé:

• Buyck et al. Increased susceptibility of Pseudomonas aeruginosa to macrolides and ketolides in eukaryotic cell culture media and biological fluids (serum, bronchoalveolar lavage) by decreased expression of OprM (efflux impairment) and increased outer membrane permeability. Clin. Infect. Dis. (2012) 55:534-542
• Buyck et al. Role of MexAB-OprM in intrinsic resistance of Pseudomonas aeruginosa to temocillin and impact on the susceptibility of strains isolated from patients suffering from cystic fibrosis. J. Antimicrob. Chemother. (2012) 67:771-775.

info : F. Van Bambeke 02.764.73.78 <francoise.vanbambeke@uclouvain.be>

Présentation des sujets de thèse des nouveaux inscrits à l'école doctorale (2ème série)

• Claire Beaufay (GNOS): Evaluation des activités antiparasitaires du Keetia leucantha et d'autres plantes utilisées en médecine traditionnelle
• Hussein Chalhoub (FACM): Pseudomonas aeruginosa et Témocilline: Etude des mécanismes de résistance intrinsèque et acquise
• Kiran Kumar Chereddi (FARG): Novel versus Conventional Polymeric Nanoparticles for the Treatment of Skin Diseases
• Céline Desmet (REMA):Une approche translationnelle pour l'étude de l'oxygénation tissulaire dans la cicatrisation de plaies chez le sujet diabétique
• Tamara Milosevic (FACM): Etude de la pharmacocinétique cellulaire des antibiotiques de la classe des oxazolidinones (accumulation, distribution subcellulaire, efflux) en relation avec leur toxicité
• Marie-Aline Neveu (REMA/FATH): Différenciation non ambigüe par imagerie entre un phénotype Warburg (glycolyse aérobie) et un phénotype oxydatif au sein de tumeurs solides..
• Vincent Van Hee (FATH) Caractérisation et ciblage thérapeutique de l’activation de NF-kB par le lactate dans les cellules tumorales impliquant le développement d’un traceur du lactate pour l’imagerie tomographique.

info: G. Muccioli 02.764.72.31 <giulio.muccioli@uclouvain.be>

Dr Yves Queneau
Institut de Chimie et Biochimie Moléculaires et Supramoléculaires,
Université de Lyon 1, France

Conception, synthèse et évaluation biologique de modulateurs du Quorum Sensing bactérien

publications en relation avec l'exposé:

• Sabbah et al. A new route towards fimbrolide analogues: importance of the exomethylene motif in LuxR dependent quorum sensing inhibition. Med. Chem. Commun. 2013, sous presse.
• Sabbah et al. Synthesis and biological evaluation as LuxR-dependent Quorum-Sensing modulators of new N-acyl-homoserine-lactone analogues based on triazole and tetrazole scaffolds. Bioorg. Med. Chem. 2012, 20, 4727-4736.
• Stevens et al. Mechanisms and Synthetic Modulators of AHL-dependent Gene Regulation. Chem. Rev. 2011, 111, 4-27.

info : F. Van Bambeke 02.764.73.78 <francoise.vanbambeke@uclouvain.be>

Dr Géraldine Piel
Pharmacie galénique, Université de Liège

Nanovecteurs polymériques et lipidiques pour le traitement du cancer: développements en cours et perspectives

publications en relation avec l'exposé:

• Van Overstraeten-Schlögel et al. Assessment of new biocompatible Poly(N-(morpholino)ethyl methacrylate)-based copolymers by transfection of immortalized keratinoc. Drug Delivery, 2012,16(2), 102-111.
• Ducat et al. Nuclear delivery of a therapeutic peptide by long circulating pH-sensitive liposomes: Benefits over classical vesicles. International Journal of Pharmaceutics. 2011, 420(2):319-32
• Dehousse et al.Comparison of chitosan/siRNA and trimethylchitosan/siRNA complexes behaviour in vitro. International Journal of Biological Macromolecules, 2010, 46, 342-349
  

info : V. Préat 02.764.73.09 <veronique.preat@uclouvain.be>

Dr Thierry Ollevier
Université Laval, Québec, Canada

Green synthetic approaches for pharmaceutical chemistry

info : B. Gallez 02.764.73.91 <bernard.gallez@uclouvain.be>

Dr Jiri Pospisil
Ecole Polytechnique, Palaiseau, France

Novel approaches to classical building blocks, natural products and their analogs

info : B. Gallez 02.764.73.91 <bernard.gallez@uclouvain.be>

Dr Raphael Frederick
Facultés Universitaires ND de la Paix, Namur

From fragment to lead: development of an innovative strategy and application to the discovery of new anticancer immunomodulators

info : B. Gallez 02.764.73.91 <bernard.gallez@uclouvain.be>

Prof. Patrizia Agostinis
Cell Death Research and Therapy lab, Department Cellular & Molecular Medicine, Faculty of Medicine,
KULeuven

Harnessing autophagy inhibition in cancer treatment

publications en relation avec l'exposé:

• Garg et al. A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death. EMBO J. 2012;31:1062-79.
• Verfaillie et al. PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress. Cell Death Differ. 2012; 19:1880-9
  

info : J. Verrax 02.764.73.35 <julien.verrax@uclouvain.be>

Dr Vincent Haufroid
Louvain Centre for Toxicology and Applied Pharmacology, IREC

Pharmacogénétique du CYP3A: applications cliniques actuelles et nouvelles perspectives

publications en relation avec l'exposé:

• Haufroid et al. CYP3A5 and ABCB1 polymorphisms and tacrolimus pharmacokinetics in renal transplant candidates : guidelines from an experimental study. Am J Transplant (2006) 6: 2706-2713.
• Elens et al. Effect of a new functional CYP3A4 polymorphism on calcineurine inhibitors dose requirements and trough blood levels in stable renal transplant patients. Pharmacogenomics (2011) 12: 1383-1396.
• Elens et al. CYP3A4*22: promising newly identified CYP3A4 variant allele for personalizing pharmacotherapy. Pharmacogenomics (2013) 14: 47-62

info : F. Van Bambeke 02.764.73.78 <francoise.vanbambeke@uclouvain.be>

Prof. Stephen Byrne
School of Pharmacy, Queen's University Belfast, Belfast, UK

Inappropriate prescribing in elderly patients: challenges and opportunities for using the STOPP and START criteria, an Irish experience

publications en relation avec l'exposé:

• Ryan et al. A comparison of the application of STOPP/START to patients' drug lists with and without clinical information.nt J Clin Pharm. 2012 Dec 9.
  

info : A. Spinewine 02.764.73.78 <anne.spinewine@uclouvain.be>

publications en relation avec l'exposé:

• Bindels LB*, Dewulf EM*, Delzenne NM. GPR43/FFA2: physio-pathological relevance and therapeutic prospects, accepted in Trends Pharmacol Sci, 2013. (*equally contributed to this work)
• Bindels et al. Gut microbiota-derived propionate reduces cancer cell proliferation in the liver, Br J Cancer, 2012: 1337-1344.
• Bindels et al. Restoring Specific Lactobacilli Levels Decreases Inflammation and Muscle Atrophy Markers in an Acute Leukemia Mouse Model, PLoS One, 2012: e37971.
  

Promoteur : N. Delzenne 02.764.73.67 <nathalie.delzenne@uclouvain.be>

Prof. Stephen Byrne
School of Pharmacy, Queen's University Belfast, Belfast, UK

The effect of an antibiotics educational initiative in primary care in Ireland

publications en relation avec l'exposé:

• Murphy et al. Antibiotic prescribing in primary care, adherence to guidelines and unnecessary prescribing--an Irish perspective. BMC Fam Pract. 2012 May 28;13:43
• Murphy et al. Influence of patient payment on antibiotic prescribing in Irish general practice: a cohort study. Br J Gen Pract. 2011 Sep;61(590):e549-55

info : A. Spinewine 02.764.73.78 <anne.spinewine@uclouvain.be>

Prof. Martine Laville
INSERM, Faculté de Médecine LYON SUD, France

Lessons from an overfeeding experiment

publications en relation avec l'exposé:

• Alligier et al. Subcutaneous Adipose Tissue Remodeling during the Initial Phase of Weight Gain Induced by Overfeeding in Humans.J Clin Endocrinol Metab. 2012 Feb;97(2):E183-92.
• Alligier et al. Visceral Fat Accumulation During Lipid Overfeeding Is Related to Subcutaneous Adipose Tissue Characteristics in Healthy Men. J Clin Endocrinol Metab. 2013 Jan 2

info : N. Delzenne 02.764.73.67 <nathalie.delzenne@uclouvain.be>

Promoteur : J. Leclercq <joelle.leclercq <joelle.leclercq@uclouvain.be>; copromoteur: P. Kienlen-Campard

Dr Emmanuelle Lautié
Pharmacognosy research group, LDRI

La rotenone : la limitation à la valorisation des graines de haricot igname?

publications en relation avec l'exposé:

• Lautié et al. (2012) Validated SPE HPLC-UV quantification of rotenone in seeds of yam bean (Pachyrhizus sp.) Food Chemistry 131(4):1531-1538
• Lautié et al. (2012) Fast microwave assisted extraction of rotenone for its quantification in seeds of yam bean (Pachyrhizus sp.) Journal of Separation Science in press

info : J. Leclercq <joelle.leclercq <joelle.leclercq@uclouvain.be>

Association of Mitogen Activated Protein kinase inhibitors with radiation therapy: focus on tumor oxygenation and multi-modal imaging markers of response to treatment

publications en relation avec l'exposé:

• Karroum et al, Tumor reoxygenation following administration of Mitogen-Activated Protein Kinase inhibitors: A rationale for combination with radiation therapy. Radiotherapy and Oncology 2012 Oct;105(1):64-71
• Karroum et al, Tumor Reoxygenation following Administration of the EGFR inhibitor, Gefitinib, in Experimental Tumors. Advances in Experimental Medicine and Biology - In press 2013.
• Karroum et al, Multimodal imaging of tumor response to Sorafenib combined with radiation therapy: comparison between diffusion-weighted MRI, choline spectroscopy and 18F-FLT PET imaging.
  Contrast Media and Molecular Imaging - In Press 2013
  

Promoteurs : B. Jordan <benedicte.jordan <benedicte.jordan@uclouvain.be> & V. Grégoire

Dr Teresinha Leal
Louvain Centre for Toxicology and Applied Pharmacology

Inflammation pulmonaire dans la mucoviscidose

publications en relation avec l'exposé:

• Lubamba et al. Immunomodulatory activity of vardenafil on induced lung inflammation in cystic fibrosis mice. J Cyst Fibros.2012; 11:266-73
• Bergamini et al. Effects of Azithromycin (AZM) on Glutathione-S-Transferases (GST)s in Cystic Fibrosis Airway Cells. Am J Respir Cell Mol Biol 2009; 41:199-206
  

info : F. Van Bambeke 02.764.73.78 <francoise.vanbambeke@uclouvain.be>