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Résumé :
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Despite good progress made in the fight against tuberculosis (TB), the disease remains a major public health threat worldwide. Comorbid diseases that increase the risk of developing active TB and have a negative impact on final treatment outcomes include HIV and diabetes mellitus. The effect of other conditions such as peptic ulcer and asthma/chronic obstructive pulmonary disease (together defined as COPD for this study) on TB is not clear. There is also little information in Uzbekistan about the interaction between these comorbidities and TB. This study was therefore carried out to assess the characteristics and treatment outcomes of TB patients with these specific comorbid conditions. This was a descriptive study of a cohort of patients with newly diagnosed pulmonary TB with specific comorbidities in the Samarkand region, Uzbekistan, from 2012 to 2013. There were 1260 patients with newly diagnosed TB, of whom 193 (15%) had comorbidities: diabetes (n = 116, 9%), HIV (n = 27, 2%), COPD (n = 29, 2%) or peptic ulcer (n = 22, 2%). Diabetes, COPD and peptic ulcer disease were mainly found in patients aged 55 years and above, while HIV coinfection was mainly found in patients aged 25–54 years. Clinical characteristics were fairly similar between those with and without comorbidities. Compared with those who had no comorbidities, patients with comorbidities had significantly reduced treatment success (78% versus 92%), a higher rate of death (9% versus 2%) and higher treatment failure (2% versus 1%)
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