{"id":3813,"date":"2022-06-07T10:33:09","date_gmt":"2022-06-07T08:33:09","guid":{"rendered":"https:\/\/sites.uclouvain.be\/morsommelab\/?p=3813"},"modified":"2023-04-27T11:25:50","modified_gmt":"2023-04-27T09:25:50","slug":"congratulations-to-francois-for-his-phd-thesis","status":"publish","type":"post","link":"https:\/\/sites.uclouvain.be\/morsommelab\/2022\/06\/07\/congratulations-to-francois-for-his-phd-thesis\/","title":{"rendered":"Congratulations to Fran\u00e7ois for his PhD thesis"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-3823 alignleft\" src=\"https:\/\/sites.uclouvain.be\/morsommelab\/wp-content\/uploads\/2023\/04\/Capture-decran-2023-04-27-a-10.35.33.png\" alt=\"\" width=\"173\" height=\"198\" \/><\/p>\n<p>Fran\u00e7ois Tyckaert is the first PhD student co-supervised by Henri-Fran\u00e7ois Renard and myself.<\/p>\n<p>Using state-of-the-art microscopy and cell biology techniques, Fran\u00e7ois could show that CD166 is a clathrin- and dynamin-independent cargo internalized via a novel endocytic mechanism that involves the BAR domain protein endophilin-A3 and the extracellular lectin galectin-8. Additionally, he could demonstrate that the actin cytoskeleton and its regulatory GTPase Rac1 dynamically associate with CD166-positive endocytic carriers and that their perturbation strongly inhibits the uptake process. He also provided evidence that microtubules and kinesin molecular motors are required to potentiate the endoA3-dependent endocytosis of CD166.<\/p>\n<div id=\"ConnectiveDocSignExtentionInstalled\" data-extension-version=\"1.0.4\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Fran\u00e7ois Tyckaert is the first PhD student co-supervised by Henri-Fran\u00e7ois Renard and myself. Using state-of-the-art microscopy and cell biology techniques, Fran\u00e7ois could show that CD166 is a clathrin- and dynamin-independent cargo internalized via a novel endocytic mechanism that involves the BAR domain protein endophilin-A3 and the extracellular lectin galectin-8. Additionally, he could demonstrate that the actin cytoskeleton and its regulatory GTPase Rac1 dynamically associate with CD166-positive endocytic carriers and that their perturbation strongly inhibits the uptake process. He also provided evidence that microtubules and kinesin molecular motors are required to potentiate the endoA3-dependent endocytosis of CD166.<\/p>\n","protected":false},"author":23,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-3813","post","type-post","status-publish","format-standard","hentry","category-non-classe"],"_links":{"self":[{"href":"https:\/\/sites.uclouvain.be\/morsommelab\/wp-json\/wp\/v2\/posts\/3813","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.uclouvain.be\/morsommelab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.uclouvain.be\/morsommelab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.uclouvain.be\/morsommelab\/wp-json\/wp\/v2\/users\/23"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.uclouvain.be\/morsommelab\/wp-json\/wp\/v2\/comments?post=3813"}],"version-history":[{"count":2,"href":"https:\/\/sites.uclouvain.be\/morsommelab\/wp-json\/wp\/v2\/posts\/3813\/revisions"}],"predecessor-version":[{"id":3923,"href":"https:\/\/sites.uclouvain.be\/morsommelab\/wp-json\/wp\/v2\/posts\/3813\/revisions\/3923"}],"wp:attachment":[{"href":"https:\/\/sites.uclouvain.be\/morsommelab\/wp-json\/wp\/v2\/media?parent=3813"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.uclouvain.be\/morsommelab\/wp-json\/wp\/v2\/categories?post=3813"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.uclouvain.be\/morsommelab\/wp-json\/wp\/v2\/tags?post=3813"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}