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(Invited talk)

Title: "High resolution microCT, and its past and future challenges in the biomedical field"

Speaker: Prof. Greet Kerckhofs (UCLouvain/iMMC, KULeuven)

Location: "Shannon" Seminar Room, Place du Levant 3, Maxwell Building, 1st floor

Date / Time (duration): Tuesday 12/06/18, 15h00 (~45')

Abstract: Biological tissues are 3D structures with complex spatial heterogeneity, for which traditional 2D imaging techniques such as standard histomorphometry are insufficient to comprehensively characterize them or assess their quality. Advanced 3D imaging is one of the enabling technologies that is of increasing importance in the biomedical field to assess tissue quality, and to provide better knowledge on the mechanisms behind tissue formation and regeneration. In this seminar, I will provide an overview of the process of implementing high resolution microCT as advanced 3D imaging tool for different biomedical applications, as well as of its optimization, both in terms of hardware (side equipment and contrast agents) and software (for image acquisition, reconstruction and analysis) specifically for different biomedical applications. I will highlight what we have achieved over the past 15 years within the KU Leuven microCT labs, but I will also discuss which the currently remaining challenges are and how we will aim to tackle (some of) them in the future.

Biography: Prof. Greet Kerckhofs is currently Assistant Professor at the Institute of Mechanics, Materials, and Civil Engineering of the UCL (Louvain-la-Neuve, Belgium), running the Biomechanics lab, and she is 10% Visiting Professor at the Dept. Materials Engineering of the KU Leuven. Moreover, she is in the scientific committee board of Prometheus, the KU Leuven division of Skeletal Tissue Engineering. She obtained her PhD in Materials Engineering at the KU Leuven in 2009 related to microCT imaging for the morphological and mechanical characterization of porous materials. She was a postdoctoral fellow at the Université de Liège in 2012-2014, after which she returned as postdoc to the KU Leuven establishing contrast-enhanced CT for the 3D visualization and morphological characterisation of non-mineralized biological tissues. Trained as an engineer, within Prometheus she has been capable of integrating biology and engineering technology (such as imaging, biomaterials testing and production/design and bioprocessing) into her research and as a result, she now belongs to the small group of researchers that have grown into a genuine interdisciplinary profile.

Her present research mainly focuses on Virtual 3D Histology using Contrast-Enhanced CT (CE-CT). She is author of 41 peer-reviewed publications, two book chapters and more than 70 contributions to international and national onferences, mostly related to microCT imaging. She has an h-index of 17 with over 1250 citations. She is co-promoter of several national and international projects, both for basic science as well as for the purchase of large equipment (the latter for approximately 3.5 million EUR – for microCT equipment). She has received a number of awards and travel grants, and as a pioneer in CE-CT-based virtual 3D histology, she has been invited as keynote speaker on several conferences as well as in different renowned international labs.

Last updated June 05, 2018, at 11:16 AM