Title: "How using DCE-MRI and registration to measure the concentration of the contrast agent ([CA]) inside the human and guinea-pigs (GP) cochlea?"
Speaker: Jérôme Plumat
Location: "TVNUM" Seminar Room (a124) Place du Levant 2, Stévin Building, 1st floor
Date / Time (duration): Monday 01/09/2014, 11h00 (~ 45')
Abstract: How using DCE-MRI and registration to measure the concentration of the contrast agent (CA) inside the human and guinea-pigs (GP) cochlea? Due to the tightness of the blood-labyrinth barrier (BLB) few medium contrast reaches the inner ear resulting to a low received signal. Furthermore, the sizes of the different compartments inside the ear require a good spatial resolution. We are currently trying to design some T1-weigthed MRI sequences and a protocol to quantify the amount of CA along the time. We have performed two classes of experiments. Firstly by using a 4.7T scanner and GP and secondly using a Siemens 3T scanner and human controls. Primarily results highlight a BLB's porosity change in GP with ear infections. Also, we are currently using registration to precisely and automatically quantify the concentration of CA in the different compartments.
Last updated September 12, 2014, at 11:53 PM