2.00 credits
20.0 h
Q1
Teacher(s)
Bertrand Luc (coordinator); Bommer Guido; Collet Jean-François; Demoulin Jean Baptiste;
Language
French
> English-friendly
> English-friendly
Prerequisites
It is the perfect follow-up of sbim2115, protein structure and function.
Main themes
This course aims to deepen the knowledge on post-translational modifications.
Content
General introduction on the importance of post-translational modifications of proteins in their regulation and function
- Mechanisms of disulfide bond formation in prokaryotes and eukaryotes
- Protein phosphorylations
- The new world of post-translational modifications resulting from metabolism (Acetylation, O-GlcNacylation)
- Mechanisms of targeted proteolysis, protein ubiquitination and related post-translational modifications
- Protein repair mechanisms (isoaspartates, glycation/deglycation) and role of rare post-translationnal modifications
- Mechanisms of disulfide bond formation in prokaryotes and eukaryotes
- Protein phosphorylations
- The new world of post-translational modifications resulting from metabolism (Acetylation, O-GlcNacylation)
- Mechanisms of targeted proteolysis, protein ubiquitination and related post-translational modifications
- Protein repair mechanisms (isoaspartates, glycation/deglycation) and role of rare post-translationnal modifications
Teaching methods
The different parts of the course will be given by lecturers who are specialists in their domains using powerpoint slides. The slides will be available for the students.
Evaluation methods
Written exam on all parts of the course
Online resources
There is no formal syllabus ! PDF versions of slides presented in the course, which cover the subject in a comprehensive way, will be made available on MoodleUCL (https://moodleucl.uclouvain.be/).
In addition, a tablet will be used to explain certain aspects of the course. The "Tablet" PDF versions of the PowerPoint files will also be made available to students via MoodleUCL.
Faculty or entity
SBIM
