Organic chemistry III

Teacher(s)

Robiette Raphaël;

Language

French

Prerequisites

It is recommended to have acquired the knowledge and skills developed in the teaching units:

LCHM1111	Chimie générale
LCHM1141	Chimie organique
LCHM1244	Chimie organique 2 : approfondissement des concepts de base
LCHM1245	Chimie organique 2 : Chimie hétéroatomique

Main themes

Frontier orbital theory.
Fukui treatment.
Thermal activation and photochemistry.
Cycloadditions: regio and stereoselectivity. 1-3 dipolar cycloadditions.
Rearrangement of Cope and related reactions.
Cationic polycyclisations.
Polymerizing cations.
Biomimetic reactions.
Radical polycyclisation.
Polymerizing radicals.
Natural antioxydants.

Learning outcomes

At the end of this learning unit, the student is able to :
1	ln the continuity of the organic chemistry II course, this course follows the study of reaction intermediates and reaction mechanisms. A first part is dedicated to pericyclic reactions and to frontier orbital theory. Connections with the physical chemistry course will be highlighted. The second part treats the reactivity of carbocations and radicals. Examples from the biochemistry course will be used to illustrate these concepts. ln both parts emphasis is put on all aspects of selectivity while creating new bonds.

Content

The chapters covered in this course are :
- Theory of molecular orbitals
- Electrocyclic reactions
- Cycloadditions
                    - [4+2]
                    - [2+2]
                    - (3+2)
- Sigmatropic rearrangements
- Chemistry of carbenes
- Radical chemistry
- Carbocations

Teaching methods

13 magistral lectures of 2h and 6 classroom exercices sessions.

Evaluation methods

Written exam

Online resources

Slides used for the magistral lectures, review articles covering the different chapters of the course as well as exercices are available on moodle.
https://moodleucl.uclouvain.be/course/view.php?id=11010

Bibliography

Les livres de référence suivants sont conseillés
- F. Carey & R. Sunberg, Advanced Organic Chemistry, 5 ème edition, Parties A & B. Disponible en ebook sur DIAL.
- S. Warren & J. Clayden, Chimie Organique, seconde édition.
Ces livres sont disponibles à la BST
Le cours ne fait appel à aucun support particulier qui serait payant et jugé obligatoire
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The following reference books are recommended
- F. Carey & R. Sunberg, Advanced Organic Chemistry, 5th edition, Parts A & B. Available as an ebook on DIAL.
- S. Warren & J. Clayden, Organic Chemistry, second edition.
These books are available at BST

The course does not use any particular material that would be paid for and considered mandatory

Teaching materials

• Slides sur moodle

Faculty or entity

CHIM