3.00 credits
25.0 h
Q1
Teacher(s)
Elens Laure; Haufroid Vincent; Hermans Emmanuel (coordinator); Lison Dominique;
Language
French
Prerequisites
The prerequisite(s) for this Teaching Unit (Unité d’enseignement – UE) for the programmes/courses that offer this Teaching Unit are specified at the end of this sheet.
Content
1. Introduction and general pharmacodynamics
Mechanisms of action of drugs
Types of receptors/targets
Relationships between receptor binding and pharmacological response
Variability of individual response
Large therapeutic classes
2. Pharmacokinetics.
Reminder of the main concepts (compliance, absorption, distribution, metabolism and excretion)
Description of the main physiological causes of inter-individual pharmacokinetic variability (Age [children, elderly], Pregnancy, Genetic polymorphisms, Drug and environmental interactions...)
Description of the main pathological causes of inter-individual pharmacokinetic variability (Renal function, Liver function, Obesity, Evolution of the disease...)
3. Toxicology
Basic concepts in toxicology: exposure, dose, danger, risk
Factors determining the toxic response to a xenobiotic
Main mechanisms of toxicity
Antidote concept
Mechanisms of action of drugs
Types of receptors/targets
Relationships between receptor binding and pharmacological response
Variability of individual response
Large therapeutic classes
2. Pharmacokinetics.
Reminder of the main concepts (compliance, absorption, distribution, metabolism and excretion)
Description of the main physiological causes of inter-individual pharmacokinetic variability (Age [children, elderly], Pregnancy, Genetic polymorphisms, Drug and environmental interactions...)
Description of the main pathological causes of inter-individual pharmacokinetic variability (Renal function, Liver function, Obesity, Evolution of the disease...)
3. Toxicology
Basic concepts in toxicology: exposure, dose, danger, risk
Factors determining the toxic response to a xenobiotic
Main mechanisms of toxicity
Antidote concept
Teaching methods
Presentation in lectures of concepts, principles and processes with illustrations from concrete examples of drugs commonly used in human medicine.
Evaluation methods
Written exam consisting of multiple choice questions with reasoning and short open-ended questions.The student will have to demonstrate mastery of his knowledge and understanding of the concepts.
The number of questions will reflect the importance and the hourly volumes of each part (Pharmacodynamics 10h, Pharmacokinetics 10h and Toxicology 5h). The final mark will take into account a weighting of the results of each part, in connection with this number of hours. Note: for students who do not present the Toxicology section (WMDS1237D), the final mark combines the markss of the Pharmacodynamics and Pharmacokinetics parts in an equivalent manner.
Any overall average less than 10/20 is rounded down to the nearest unit.
The number of questions will reflect the importance and the hourly volumes of each part (Pharmacodynamics 10h, Pharmacokinetics 10h and Toxicology 5h). The final mark will take into account a weighting of the results of each part, in connection with this number of hours. Note: for students who do not present the Toxicology section (WMDS1237D), the final mark combines the markss of the Pharmacodynamics and Pharmacokinetics parts in an equivalent manner.
Any overall average less than 10/20 is rounded down to the nearest unit.
Online resources
The documents projected during the course are available on the Moodle platform. Reference books are suggested at the start of each part of the course.
Bibliography
Goodman and Gilman's Pharmacological Basis of Therapeutics, Twelfth Edition, 2010
Casarett and Doull's Toxicology - The basic science of poisons, 9th Edition, 2019
Urs A. Boelsterli - Mechanistic Toxicology: The molecular basis of how chemicals disrupt biological targets, 2nd Edition, 2007
Casarett and Doull's Toxicology - The basic science of poisons, 9th Edition, 2019
Urs A. Boelsterli - Mechanistic Toxicology: The molecular basis of how chemicals disrupt biological targets, 2nd Edition, 2007
Teaching materials
- .
Faculty or entity
MED
