Teacher(s)

Hermans Emmanuel (coordinator); Lison Dominique; Wallemacq Pierre;

Language

French

Prerequisites

The prerequisite(s) for this Teaching Unit (Unité d’enseignement – UE) for the programmes/courses that offer this Teaching Unit are specified at the end of this sheet.

Content

1. Introduction and general pharmacodynamics
Mechanisms of action of drugs
Types of receptors/targets
Relationships between receptor binding and pharmacological response
Variability of individual response
Large therapeutic classes
2. Pharmacokinetics.
Reminder of the main concepts (compliance, absorption, distribution, metabolism and excretion)
Description of the main physiological causes of inter-individual pharmacokinetic variability
Age (children, elderly)
Pregnancy
Genetic polymorphism (PK and PD)
Description of the main pathological causes of inter-individual pharmacokinetic variability
Renal function
Liver function
Obesity
Evolution of the disease
Drug and environmental interactions
3. Toxicology
Basic concepts in toxicology: exposure, dose, danger, risk
Factors determining the toxic response to a xenobiotic
Main mechanisms of toxicity
Antidote concept

Teaching methods

Due to the COVID-19 crisis, the information in this section is particularly likely to change.

Presentation in lectures of concepts, principles and processes with illustrations from concrete examples of drugs commonly used in human medicine.

Evaluation methods

Due to the COVID-19 crisis, the information in this section is particularly likely to change.

Written exam, multiple choice questions with reasoning, open and short answer questions.
The student will have to demonstrate mastery of his knowledge and understanding of the concepts.
Any overall average less than 10/20 is rounded down to the nearest unit.

Online resources

The documents projected during the course are available on the Moodle platform. Reference books are suggested at the start of each part of the course.

Bibliography

Goodman and Gilman's Pharmacological Basis of Therapeutics, Twelfth Edition, 2010
Casarett and Doull's Toxicology - The basic science of poisons, 9th Edition, 2019
Urs A. Boelsterli - Mechanistic Toxicology: The molecular basis of how chemicals disrupt biological targets, 2nd Edition, 2007

Teaching materials

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Faculty or entity

MED