Teacher(s)

Frédérick Raphaël; Frédérick Raphaël (compensates Lambert Didier); Lambert Didier; Muccioli Giulio (coordinator);

Language

French

Prerequisites

organic chemistry and medicinal chemistry

Main themes

The general theme is drug discovery / drug design. During this EU the students will approach one or more drug discovery / drug design methodologies of their choice through a work allowing the deepening of the chosen techniques / methods. 
In addition, all students participating in the EU will have the opportunity to have an overview of these methods through the presentation of each student's work.
In a non-exhaustive way the students will have the opportunity to deepen, according to their interest, techniques allowing the identification of hits for a given target (high throughput screening; computer-aided design (de novo design), ...), hit-to-lead strategies (e.g. structure-activity relationships; docking; etc).  

Aims

At the end of this learning unit, the student is able to :
1	To interpret the results of a scientific article dealing with the development of a medication To propose a strategy to identify a new potential therapeutic target To propose a strategy to identify new leads for a given target (receptor, enzyme) To propose a strategy to optimize the activity of a compound for its target. To present orally a "fictitious" research project based on the theme chosen.

Content

• Lipidomics applied to the discovery of novel targets
• Exploring the proteome looking for novel targets :  the enzymes ' the receptors
• Proteins as therapeutic target
  • Determination of their 3D structure
  • Role of protein's 3D models in drug design
• The interest of establishing structure-activity relationships in drug design

Faculty or entity

FARM