The prerequisite(s) for this Teaching Unit (Unité d’enseignement – UE) for the programmes/courses that offer this Teaching Unit are specified at the end of this sheet.
Mechanisms of action of drugs
Types of receptors/targets
Relationships between receptor binding and pharmacological response
Variability of individual response
Large therapeutic classes
Reminder of the main concepts (compliance, absorption, distribution, metabolism and excretion)
Description of the main physiological causes of inter-individual pharmacokinetic variability
Age (children, elderly)
Genetic polymorphism (PK and PD)
Description of the main pathological causes of inter-individual pharmacokinetic variability
Evolution of the disease
Drug and environmental interactions
Basic concepts in toxicology: exposure, dose, danger, risk
Factors determining the toxic response to a xenobiotic
Main mechanisms of toxicity
Due to the COVID-19 crisis, the information in this section is particularly likely to change.Presentation in lectures of concepts, principles and processes with illustrations from concrete examples of drugs commonly used in human medicine.
Due to the COVID-19 crisis, the information in this section is particularly likely to change.Written exam, multiple choice questions with reasoning, open and short answer questions.
The student will have to demonstrate mastery of his knowledge and understanding of the concepts.
Any overall average less than 10/20 is rounded down to the nearest unit.
Casarett and Doull's Toxicology - The basic science of poisons, 9th Edition, 2019
Urs A. Boelsterli - Mechanistic Toxicology: The molecular basis of how chemicals disrupt biological targets, 2nd Edition, 2007