Note from June 29, 2020
Although we do not yet know how long the social distancing related to the Covid-19 pandemic will last, and regardless of the changes that had to be made in the evaluation of the June 2020 session in relation to what is provided for in this learning unit description, new learnig unit evaluation methods may still be adopted by the teachers; details of these methods have been - or will be - communicated to the students by the teachers, as soon as possible.
Although we do not yet know how long the social distancing related to the Covid-19 pandemic will last, and regardless of the changes that had to be made in the evaluation of the June 2020 session in relation to what is provided for in this learning unit description, new learnig unit evaluation methods may still be adopted by the teachers; details of these methods have been - or will be - communicated to the students by the teachers, as soon as possible.
3 credits
30.0 h
Q2
Teacher(s)
Frédérick Raphaël; Lambert Didier; Muccioli Giulio (coordinator);
Language
French
Main themes
The purpose of this medicinal chemistry course is to enable the student to understand, via selected examples, the different strategies used in medicinal chemistry to discover and optimize a drug. We will cover topics ranging from the choice of the therapeutic target of interest to the marketed molecule, via the discovery of potentially interesting molecules (a.k.a. 'hits') and their optimization into 'leads'.
It will also discuss aspects of the interaction between molecules and targets to emphasize their importance in the action of drugs, as well as the strategies of the medicinal chemist to modulate the passage of the blood-brain barrier.
Aims
At the end of this learning unit, the student is able to : | |
| 1 |
- Give to the student the appropriate knowledge:
- Give to the student the appropriate knowledge:
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The contribution of this Teaching Unit to the development and command of the skills and learning outcomes of the programme(s) can be accessed at the end of this sheet, in the section entitled “Programmes/courses offering this Teaching Unit”.
Content
This course addresses important concepts in the context of "drug discovery" for pharmaceutical sciences undergraduate students. While the more specialized notions are discussed in elective courses, this course will give a glimpse of the methodologies used to develop, characterize, and improve a drug.
Among the elements discussed, we can mention:
1. Target identification by the « omic » approaches
2. Orphan GPCRs as drug targets
3. Real world Drug Discovery
4. Medicinal chemistry in the academic world
5. Structure-based and fragment-based drug design
6. Lead-like properties
7. BBB crossing by drugs: from evaluation to optimization and prodrug strategies
8. From in-vitro to in-vivo and to the patient
9. Medicinal chemistry in the Pharma industry
10. Big size drugs
Among the elements discussed, we can mention:
1. Target identification by the « omic » approaches
2. Orphan GPCRs as drug targets
3. Real world Drug Discovery
4. Medicinal chemistry in the academic world
5. Structure-based and fragment-based drug design
6. Lead-like properties
7. BBB crossing by drugs: from evaluation to optimization and prodrug strategies
8. From in-vitro to in-vivo and to the patient
9. Medicinal chemistry in the Pharma industry
10. Big size drugs
Teaching methods
Courses will be given by experts in the field, including from the pharma industry
Evaluation methods
Evaluation by a written exam
Online resources
An adapted version of the material presented during the lessons is available on the "moodle" platform.
Teaching materials
- une version des supports présentés est disponible sur moodle
Faculty or entity
FARM
