Note from June 29, 2020
Although we do not yet know how long the social distancing related to the Covid-19 pandemic will last, and regardless of the changes that had to be made in the evaluation of the June 2020 session in relation to what is provided for in this learning unit description, new learnig unit evaluation methods may still be adopted by the teachers; details of these methods have been - or will be - communicated to the students by the teachers, as soon as possible.
Although we do not yet know how long the social distancing related to the Covid-19 pandemic will last, and regardless of the changes that had to be made in the evaluation of the June 2020 session in relation to what is provided for in this learning unit description, new learnig unit evaluation methods may still be adopted by the teachers; details of these methods have been - or will be - communicated to the students by the teachers, as soon as possible.
6 credits
50.0 h + 10.0 h
Q1
Teacher(s)
Delzenne Nathalie (coordinator);
Language
French
Prerequisites
The prerequisite(s) for this Teaching Unit (Unité d’enseignement – UE) for the programmes/courses that offer this Teaching Unit are specified at the end of this sheet.
Main themes
Sub-sections :
- A. General aspects : physico-chemical aspects of biochemical processes (including enzyme kinetics and classification, bioenergetics);
- B. Molecular Biology (in Eukarya) : from genes to active proteins (structure and regulation); interest of molecular biology in diagnosis and drug development.
- C. Metabolism : description, regulation, and tissue specificity of key anabolic and catabolic pathways.
- D. Integrated view of metabolic pathways in the whole organism; modulation in several (patho)physiological situations.
Content
A. Principles of chemistry applicable to biological processes. Concepts of molecular interactions, enzyme kinetics, and bioenergetics in the context of drug discovery (drug metabolism, signal transduction, synthetic peptides, development of enzyme inhibitors). B. Structure and functions of genes and nucleic acids; genome replication; principles/regulation of gene expression and protein synthesis in eucaryotes and procaryotes. C Description and regulation of carbohydrates, lipids, amino-acids , and nucleotides metabolism at the molecular, cellular and tissue level ; control of energy homeostasis; hormonal regulation and cell signaling; metabolic fluxes. D. Metabolic adaptation to physiological situations (such as nutritional status, stress
); illustration of inter-organs cooperation (liver, adipose tissue, muscle, brain
). Practical laboratory exercises (enzymes kinetics, molecular biology) and seminars (use of reference book and website; oral presentation of case-study)
Other information
Other elements
Cellular biology ; organic and general chemistry.
Evaluation
Evaluation of experimental knowledge during the period of practical exercise.
Written exam with questions integrating all aspects (A to D) .
Support
Notes including key figures, power point presentations, and summary of each chapter.
Ouvrages de référence ; sites internet et adresses d'organismes intéressants :
Biochemical Pathways Eds Gerhard Michal. Wiley press
Online resources
The slides presented in the course are available on MoodleUCL (https://moodleucl.uclouvain.be/).
Bibliography
Support de cours obligatoire : diapositives des cours disponibles sur Moodle, en version pdf
Faculty or entity
FASB
Programmes / formations proposant cette unité d'enseignement (UE)
Title of the programme
Sigle
Credits
Prerequisites
Aims
Bachelor in Biomedicine
