Note from June 29, 2020
Although we do not yet know how long the social distancing related to the Covid-19 pandemic will last, and regardless of the changes that had to be made in the evaluation of the June 2020 session in relation to what is provided for in this learning unit description, new learnig unit evaluation methods may still be adopted by the teachers; details of these methods have been - or will be - communicated to the students by the teachers, as soon as possible.
Although we do not yet know how long the social distancing related to the Covid-19 pandemic will last, and regardless of the changes that had to be made in the evaluation of the June 2020 session in relation to what is provided for in this learning unit description, new learnig unit evaluation methods may still be adopted by the teachers; details of these methods have been - or will be - communicated to the students by the teachers, as soon as possible.
3 credits
22.5 h
Q2
Teacher(s)
Frédérick Raphaël; Lambert Didier; Muccioli Giulio (coordinator);
Language
French
Prerequisites
organic chemistry and medicinal chemistry
Main themes
The teacher(s) will discuss first the different techniques allowing the discovery of novel therapeutic targets (lipidomic ' proteomic ' deorphanization), second the methods allowing the identification of hits for a given molecular target (high-throughput screening ; computer assisted de novo drug design); finally the strategies allowing to optimize a hit ('hit to lead') will be discussed (structures-activity relationships ; docking; ')
Aims
At the end of this learning unit, the student is able to : | |
| 1 |
At the end of the activity the student will be able to
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The contribution of this Teaching Unit to the development and command of the skills and learning outcomes of the programme(s) can be accessed at the end of this sheet, in the section entitled “Programmes/courses offering this Teaching Unit”.
Content
- Lipidomics applied to the discovery of novel targets
- Exploring the proteome looking for novel targets : the enzymes ' the receptors
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Proteins as therapeutic target
- Determination of their 3D structure
- Role of protein's 3D models in drug design
- The interest of establishing structure-activity relationships in drug design
Faculty or entity
FARM
