2 credits
20.0 h
Q1
Teacher(s)
Lemaigre Frédéric coordinator;
Language
French
Prerequisites
fundamental principles in cell and molecular biology, and in biochemistry (metabolism) taught during the baccalaureate.
Main themes
The course describes the molecular and cell biology of intercellular signaling in normal condition and cancer, the mode of action of anti-cancer drugs, the interaction between tumor cells and their micro-environment, angiogenesis and metabolic anomalies resulting from the adaptation of tumor cells to their micro-environment (hypoxia and acidosis). The course will also address the issue of tumor cell immortality.
Content
The course describes the molecular and cell biology of intercellular signaling in normal condition and cancer, the mode of action of anti-cancer drugs, the interaction between tumor cells and their environment, angiogenesis and metabolic anomalies resulting from the adaptation of tumor cells to their micro-environment (hypoxia and acidosis). The course also addresses the issue of tumor cell immortality.
At the end of the course, the students are expected to master the main intercellular signaling pathways, the interactions between tumor cells and blood vessels, the principles of cell immortality and the determinants of tumor cell metabolism; to understand and explain how perturbed intercellular signaling, abnormal metabolism and cell immortality contribute to tumor progression and metastasis; to understand and explain how anticancer drug modulate intercellular signaling; to be able to design an experimental approach aiming at the identification of therapeutic targets; to use the acquired knowledge to address new issues.
At the end of the course, the students are expected to master the main intercellular signaling pathways, the interactions between tumor cells and blood vessels, the principles of cell immortality and the determinants of tumor cell metabolism; to understand and explain how perturbed intercellular signaling, abnormal metabolism and cell immortality contribute to tumor progression and metastasis; to understand and explain how anticancer drug modulate intercellular signaling; to be able to design an experimental approach aiming at the identification of therapeutic targets; to use the acquired knowledge to address new issues.
Teaching methods
Lecture courses
Evaluation methods
Written exam with open questions evaluating the student's knowledge and the student's ability to implement the knowledge to solve a biological problem.
Other information
Prerequisite: fundamental principles in cell and molecular biology, and biochemistry (metabolism) taught duting the baccalaureate. Lectures are given in french, slides and notes are exclusively in english. The exam questions can be given in english upon request.
Online resources
Slides presented during courses and teaching notes are made available on http://moodleucl.uclouvain.be/
Bibliography
- fichier reprenant les notes de cours disponible sur moodle
Faculty or entity
FASB
