Teacher(s)

Constantinescu Stefan; Decottignies Anabelle; Feron Olivier; Lemaigre Frédéric coordinator; Sonveaux Pierre;

Language

French

Prerequisites

fundamental principles in cell and molecular biology, and in biochemistry (metabolism) taught during the baccalaureate.

Main themes

The course describes the molecular and cell biology of intercellular signaling in normal condition and cancer, the mode of action of anti-cancer drugs, the interaction between tumor cells and their micro-environment, angiogenesis and metabolic anomalies resulting from the adaptation of tumor cells to their micro-environment (hypoxia and acidosis). The course will also address the issue of tumor cell immortality.

Aims

At the end of this learning unit, the student is able to :
1	The course is expected to provide the students with the competence to: - master the main intercellular signaling pathways, the interactions between tumor cells and blood vessels, the principles of cell immortality and the determinants of tumor cell metabolism; - understand and explain how perturbed intercellular signaling, abnormal metabolism and cell immortality contribute to to tumor initiation and progression, and metastasis; - understand and explain how anti-cancer drug modulate intercellular signaling; - be able to design an experimental approach aiming at the identification of therapeutic targets; - be able to critically address an oral presentation or article in the field; - use the acquired knowledge to address knew issues.

The contribution of this Teaching Unit to the development and command of the skills and learning outcomes of the programme(s) can be accessed at the end of this sheet, in the section entitled “Programmes/courses offering this Teaching Unit”.

Content

The course describes the molecular and cell biology of intercellular signaling in normal condition and cancer, the mode of action of anti-cancer drugs, the interaction between tumor cells and their environment, angiogenesis and metabolic anomalies resulting from the adaptation of tumor cells to their micro-environment (hypoxia and acidosis). The course also addresses the issue of tumor cell immortality.
At the end of the course, the students are expected to master the main intercellular signaling pathways, the interactions between tumor cells and blood vessels, the principles of cell immortality and the determinants of tumor cell metabolism; to understand and explain how perturbed intercellular signaling, abnormal metabolism and cell immortality contribute to tumor progression and metastasis; to understand and explain how anticancer drug modulate intercellular signaling; to be able to design an experimental approach aiming at the identification of therapeutic targets;  to use the acquired knowledge to address new issues.

Teaching methods

Lecture courses

Evaluation methods

Written exam with open questions evaluating the student's knowledge and the student's ability to implement the knowledge to solve a biological problem.

Other information

Prerequisite: fundamental principles in cell and molecular biology, and biochemistry (metabolism) taught duting the baccalaureate. Lectures are given in french, slides and notes are exclusively in english. The exam questions can be given in english upon request.

Online resources

Slides presented during courses and teaching notes are made available on http://moodleucl.uclouvain.be/

Bibliography

• fichier reprenant les notes de cours disponible sur moodle

The biology of Cancer, R.A. Weinberg, Garland Publishing

Teaching materials

• fichier reprenant les notes de cours disponible sur moodle

Faculty or entity

FASB