3 credits
30.0 h + 10.0 h
Q1
Teacher(s)
De Smet Charles; Lemaigre Frédéric; Michiels Thomas coordinator;
Language
French
Prerequisites
Notions of general biology and cytology
The prerequisite(s) for this Teaching Unit (Unité d’enseignement – UE) for the programmes/courses that offer this Teaching Unit are specified at the end of this sheet.
The prerequisite(s) for this Teaching Unit (Unité d’enseignement – UE) for the programmes/courses that offer this Teaching Unit are specified at the end of this sheet.
Main themes
For prokaryotes as well as eukaryotes :
- structure of the DNA and genome organization ;
- mechanisms and signals of DNA replication ; transcription ; translation
(typical genetic flux DNA-RNA-protein and post-translational modification)
- epigenetic regulation
Aims
At the end of this learning unit, the student is able to : | |
| 1 |
Objectives of this class include the learning of basic principles of molecular biology for eukaryotic and prokaryotic organisms. The student will be able |
The contribution of this Teaching Unit to the development and command of the skills and learning outcomes of the programme(s) can be accessed at the end of this sheet, in the section entitled “Programmes/courses offering this Teaching Unit”.
Content
In prokaryotes and eukaryotes : structure of nucleic acids ; chromatin organization; DNA replication; gene organization ; RNA transcription and its regulation ; types of RNAs (mRNA, rRNA and tRNA), the process of mRNA translation ; post-translational modifications and protein targeting in the cell ; epigenetic regulation of gene expression by DNA methylation, histone modification, and others, and regulation of these processes.
Teaching methods
Regular courses with use of slides and blackboard
Sessions are organized to make the student acquainted with nucleotide sequence analysis and to the use of computer softwares for simple sequence manipulations and analyses
Sessions are organized to make the student acquainted with nucleotide sequence analysis and to the use of computer softwares for simple sequence manipulations and analyses
Evaluation methods
The evaluation of students takes place through a written exam. On top of basic knowledge in molecular biology , the exam will evaluate, through exercices, the student’s ability to use the matter that was teached.
Bibliography
- fichier reprenant les diapositives de cours, disponible sur Moodle
Manuel d'exercices pratiques distribués par les enseignants.
- text file and illustrations available as pdf files on the Moodle platform
- textbook : Biochimie Génétique. Biologie Moléculaire. J. Etienne et al. Editions Masson, available at the medical school library (no longer edited)
- files with exercices on the Moodle platform
Teaching materials
- fichier reprenant les diapositives de cours, disponible sur Moodle
Faculty or entity
FASB
Programmes / formations proposant cette unité d'enseignement (UE)
Title of the programme
Sigle
Credits
Prerequisites
Aims
Bachelor in Biomedicine
