Teacher(s)

Bindels Laure;

Language

French

Main themes

A.           This part of the class aims to introduce the basic concepts in toxicology that will allow the students to understand the rational of the current legal toxicological tests. Mechanisms of toxicity will be discussed and analyzed at various levels, from the generation of reactive species and their interactions with biological macromolecules, to the targeting of specific organs and the development of cancer and developmental malformations. Concepts related to risk evaluation are presented through the discussion and analysis of the results of in vivo and in vitro tests.
B.            In this part of the class, students are reminded of some basic notions of genetics, including the definition of various types of polymorphism (SNP, CNV, ..). The class focusses mainly on the influence of genetic polymorphisms on the clinical response to drug therapy (drug efficacy and side effects occurrence). Future prospects in personalized medicine are also presented.

Bibliography

• Les dias du cours et les articles scientifiques vus au cours sont disponibles sur Moodle.

Le principal livre de reference est : Burcham, Introduction to Toxicology, 2014, pdf disponible sur Moodle et le site de la bibliothèque

Faculty or entity

FARM