At the end of this learning unit, the student is able to : | |
| 1 | a. Contribution of the activity to the AA (AA of the programme) 1.1, 1.2, 1.4, 1.5 3.1, 3.4, 3.6 à 3.9 6.1, 6.2., 6.4 à 6.7
b. Specific formulation for this activity to the AA of the programme (maximum 10)
At the end of this learning activity, the student will be able to: - Explain, with an integrated and transversal vision, the main challenges of nanotechnology and nanosciences in the broad sense (nanoelectronic, nanomaterials, nanobiotechnology), - Explain the principles of the different nanofabrication methods (top-down vs bottom-up), and evaluate their throughput. - Compare the physical principles of nanocharacterization methods (scanning probes, fluorescence), and define their advantages and limitations, as well as their complementarity. - Interpret the data obtained via these different techniques. Justify with examples. - Propose an integrated vision of the main applications of nanobiotechnology (BioMEMS,Nanoparticles, Biomolecular Machines), while speculating on their long term feasibility (science vs science fiction). - Formulate a critical synthesis of scientific articles which represent major breakthrough in nanobiotechnology. - In groups of 2 or 3 students, criticize an article in written (written report of 5 pages) and oral (talk of 15 min) forms. Estimate the strengths and weaknesses of the article. Criticize the methodology, the results (originality, quality, reproducibility and statistics) and their interpretation (is the discussion founded or not). Speculate on the perspectives (basic or applied research) offered by the study. |
The contribution of this Teaching Unit to the development and command of the skills and learning outcomes of the programme(s) can be accessed at the end of this sheet, in the section entitled “Programmes/courses offering this Teaching Unit”.
Definition, history, budgets / Expected applications / From micro- to nanotechnologies / Three main fields : nanoelectronics, nanomaterials, nanobiotechnology
II. Nanofabrication methods
II.1. Top-down: lithographies
Photolithography / Electronic lithography / Soft lithography / Dip-pen nanolithography
II.2. Bottom-up: self-assembly and supramolecular chemistry
Self-assembled monolayers (SAMs) / Supramolecular chemistry / Nanostructured polymer systems / Q dots / Colloidal lithography / DNA assembly / 2D protein arrays (S-layers) / Lipid films / Layers of adsorbed proteins
III. Nanocharacterization methods
Scanning tunnelling microscopy (STM) / Atomic force microscopy (AFM) / Scanning near-field optical microscopy (SNOM) / other microscopies at the single molecule level
IV. Applications and perspectives
IV.1. Biosensors, microfluidics, BioMEMS (detection: mechanical, electrical, optical)
IV.2. Nanoparticles
Quantum dots for bio-imaging / Detection of proteins based on nanoparticles
IV.3. Biomolecular machines
F1-ATPase / Actin motors / Kinesin motors / DNA nanoactuators
