B. In this part of the class, students are reminded of some basic notions of genetics, including the definition of various types of polymorphism (SNP, CNV, ..). The class focusses mainly on the influence of genetic polymorphisms on the clinical response to drug therapy (drug efficacy and side effects occurrence). Future prospects in personalized medicine are also presented.
At the end of this learning unit, the student is able to : | |
| 1 | At the end of this teaching unit, the student will be able: - to explain the molecular mechanisms leading to a toxic response. - to summarize the procedures of risk evaluation. - to justify the toxicity of specific compounds for one organ in particular using evidence-based and scientific arguments. - to build a valid experimental plan to evaluate the toxicity of a compound and the underlying mechanisms. - to critically evaluate the relevance of an experimental plan aiming to test the toxicity of a given compound. - to formulate reasoned conclusions on the basis of a table presenting the results of a toxicological test. - to understand (1) the source of diversity due to the human genome and (2) the importance of taking into account this variability to explain the inter-individual difference in the clinical response to drug therapy. The contribution of this Teaching Unit to the development and command of the skills and learning outcomes of the programme(s) can be accessed at the end of this sheet, in the section entitled ¿Programmes/courses offering this Teaching Unit¿. |
The contribution of this Teaching Unit to the development and command of the skills and learning outcomes of the programme(s) can be accessed at the end of this sheet, in the section entitled “Programmes/courses offering this Teaching Unit”.
- Les dias du cours et les articles scientifiques vus au cours sont disponibles sur Moodle.
- Les dias du cours et les articles scientifiques vus au cours sont disponibles sur Moodle.
