3 credits
30.0 h
Q1
Teacher(s)
Leclercq Joëlle coordinator; Muccioli Giulio; Servais Anne-Catherine (compensates Leclercq Joëlle);
Language
French
Prerequisites
- Organic chemistry
- Introduction to analytical chemistry, instrumental analysis
Main themes
The main methods and norms used for purity and quality control of drugs (qualitative and quantitative analysis of impurities, assays,') will be explained
Aims
At the end of this learning unit, the student is able to : | |
| 1 | - Give to the student the appropriate knowledge:
|
The contribution of this Teaching Unit to the development and command of the skills and learning outcomes of the programme(s) can be accessed at the end of this sheet, in the section entitled “Programmes/courses offering this Teaching Unit”.
Content
- Drugs quality control ' Pharmacopoeia : general aspects
- Purity of drugs and main degradation pathways
- Identification methods (infra red spectroscopy, nuclear magnetic resonance)
- General identification reactions
- Separation methods (liquid-liquid and solid-liquid extractions, liquid, supercritical and gaz chromatographies, electrophoresis).
- Quantification methods and validation of analytical methods
- Introduction to mass spectrometry (MS), coupling of MS with separation methods
- Tests
- General monographs
- Discussion of monographs
- Examples of the main routes of chemical and physical degradation of a drug
Teaching methods
Teaching method: theoretical teaching
Evaluation methods
Evaluation by a written exam and exercises
Bibliography
- onglet spécifique sur moodle avec supports de cours obligatoires
Teaching materials
- onglet spécifique sur moodle avec supports de cours obligatoires
Faculty or entity
FARM
