At the end of this learning unit, the student is able to :
This course will serve to introduce important notions and concepts in the field of supramolecular chemistry. The goals of this course are 1) to familiarize students to the different methods and types of chemical systems used for the assembly of complicated molecular architectures and functional molecules; 2) to help students obtain the essential knowledge needed to critically examine modern scientific literature related to supramolecular chemistry; and 3) show how the notions and tools of supramolecular chemistry are applied in other areas of chemistry and biology.
The contribution of this Teaching Unit to the development and command of the skills and learning outcomes of the programme(s) can be accessed at the end of this sheet, in the section entitled “Programmes/courses offering this Teaching Unit”.
1) Introduction/definition of Supramolecular chemistry (interactions beyond the molecule, modern description of non-covalent interactions 'energy/thermodynamic considerations, media dependence, cooperativity). 2) Tools of supramolecular chemistry/Quantifying inter/intramolecular interactions (Spectroscopic and analytical methods used in supramolecular chemistry including modern/advanced NMR techniques; titration studies and determination of stoichiometry/binding constants in 1:1, 2:1, 1:2 systems ; more complicated equilibria ; kinetic versus thermodynamic stability, kinetics/affinity regimes and choice of methods). 3) Molecules interacting with each other - defining molecular recognition and host-guest chemistry; recognition of cationic/anionic/neutral molecules, including ion pairs; molecular design aspects for selectivity; role in biology and enzymes). 4) Self-assembly/self-organization ' classifications and examples, strategies for molecular assemblies, metal/ligand/template directed synthesis, self-replication, dynamic combinatorial chemistry, higher order structures including foldamers and helicates, factors related to structural stability, folding/unfolding, and fluxionality; mechanically linked/interlocked systems). 5) Molecular machines and functional supramolecular assemblies. 6) Supramolecular chemistry and catalysis (enzymes, biomimetics, structural cooperativity).
- A written report on the role of supramolecular chemistry in an area of their choice (80 %)
- Their participation during the quadrimester (20%)
-The evaluation of the participation during the quadrimester is based on the in class discussions concerning the assigned scientific articles relevant for each topic and on the completion of problem sets.
Texte de référence: Jonathan W. Steed, Jerry L. Atwood, 'Supramolecular Chemistry', 2nd Edition; ISBN: 978-1-118-68150-3