3 credits
30.0 h
Q2
Teacher(s)
Frédérick Raphaël; Lambert Didier; Muccioli Giulio coordinator;
Language
French
Main themes
The purpose of this medicinal chemistry course is to enable the student to understand, via selected examples, the different strategies used in medicinal chemistry to discover and optimize a drug. We will cover topics ranging from the choice of the therapeutic target of interest to the marketed molecule, via the discovery of potentially interesting molecules (a.k.a. 'hits') and their optimization into 'leads'.
It will also discuss aspects of the interaction between molecules and targets to emphasize their importance in the action of drugs, as well as the strategies of the medicinal chemist to modulate the passage of the blood-brain barrier.
Aims
At the end of this learning unit, the student is able to : | |
| 1 | - Give to the student the appropriate knowledge:
The contribution of this Teaching Unit to the development and command of the skills and learning outcomes of the programme(s) can be accessed at the end of this sheet, in the section entitled ¿Programmes/courses offering this Teaching Unit¿. - Give to the student the appropriate knowledge:
The contribution of this Teaching Unit to the development and command of the skills and learning outcomes of the programme(s) can be accessed at the end of this sheet, in the section entitled ¿Programmes/courses offering this Teaching Unit¿. |
The contribution of this Teaching Unit to the development and command of the skills and learning outcomes of the programme(s) can be accessed at the end of this sheet, in the section entitled “Programmes/courses offering this Teaching Unit”.
Content
1. Target identification by the « omic » approaches
2. Orphan GPCRs as drug targets
3. Real world Drug Discovery
4. Medicinal chemistry in the academic world
5. Structure-based and fragment-based drug design
6. Lead-like properties
7. BBB crossing by drugs: from evaluation to optimization and prodrug strategies
8. From in-vitro to in-vivo and to the patient
9. Medicinal chemistry in the Pharma industry
10. Big size drugs
2. Orphan GPCRs as drug targets
3. Real world Drug Discovery
4. Medicinal chemistry in the academic world
5. Structure-based and fragment-based drug design
6. Lead-like properties
7. BBB crossing by drugs: from evaluation to optimization and prodrug strategies
8. From in-vitro to in-vivo and to the patient
9. Medicinal chemistry in the Pharma industry
10. Big size drugs
Teaching methods
Courses will be given by experts in the field, including from the pharma industry
Evaluation methods
Evaluation by a written exam
Faculty or entity
FARM
