Biochemistry II : metabolic pathways and their regulation

lbir1321  2017-2018  Louvain-la-Neuve

Biochemistry II : metabolic pathways and their regulation
3 credits
30.0 h + 15.0 h
Q1
Teacher(s)
Ghislain Michel coordinator; Larondelle Yvan;
Language
French
Prerequisites
Course of structural biochemistry and basic knowledge of organic chemistry
LCHM1241C  Chimie organique
LBIR1250  Biochimie I

The prerequisite(s) for this Teaching Unit (Unité d’enseignement – UE) for the programmes/courses that offer this Teaching Unit are specified at the end of this sheet.
Main themes
-Metabolism is a linked series of chemical reactions within living organisms. These enzyme-catalysed reactions allow the cells to break down fuel molecules to produce energy (catabolism). The energy is then used to build up cell's components (anabolism).
- The course describes the types of chemical reactions, the role of enzymes and cofactors and their organisation into metabolic pathways.
- The course explains the transformation of foodstuffs into simple oxidized products and energy using basic concept of thermodynamics and bioenergetics.
- The course gives several examples of the variability of metabolism between different organs or organisms and the regulatory role of hormones.
Aims

At the end of this learning unit, the student is able to :

1

a. Contribution de l¿activité au référentiel AA (AA du programme)

1.1 ; 1.3

3.2 ; 3.3, 3.6, 3.7 ; 3.8

6.5

b. Formulation spécifique pour cette activité des AA du programme (maximum 10)

At the end of this course, students will be able to explain how the set of chemical and energy transformations within the cells allow growth and fitness to their environment. They will be also able to resolve case-oriented problems in physiology and biotechnology. These learning outcomes will be developed through:

- Learning of the chemical reactions constitutive of the main metabolic pathways

- Comparison of the metabolism activity between organs and model organisms

-Integration of metabolic pathways according to determined physiological conditions

- Understanding of the regulatory mechanisms induced by changes in external or internal milieux

-Working out a set of metabolic reactions to produce a defined compound

- Measurement of metabolic activity by using adequate methods and equipment
 

The contribution of this Teaching Unit to the development and command of the skills and learning outcomes of the programme(s) can be accessed at the end of this sheet, in the section entitled “Programmes/courses offering this Teaching Unit”.
Content
Bioenergetics basic concepts; transport across biological membranes, glycolysis and fermentation, phosphogluconate pathway, gluconeogenesis, degradation and synthesis of glycogen, Krebs cycle, glyoxylate cycle, respiratory chain and oxidative phosphorylation, lipid b-oxidation and synthesis, urea cycle, amino acid degradation and synthesis, metabolism of nitrogen compounds
Students are trained to measure the metabolic activity of a model organism through laboratory sessions. 
Teaching methods
Lectures will be given in a classroom. They consist of ex cathedra speeches and solved problems. The laboratory sessions aim at developing a scientific reasoning behaviour and improving classroom communication skills. Students are given a detailed evaluation of their performance. The learning of basic concepts and vocabulary in English is stimulated.
Evaluation methods
The written examination consists of a series of questions that require concise or detailed answers and problems solving ability. The performance developed during the laboratory training sessions are evaluated independently, via the laboratory report.
Online resources
Moodle
Bibliography
Un syllabus, des copies papier des diaporamas et le manuel pour les séances de laboratoire sont disponibles sur icampus.
Le cours ne fait appel à aucun support particulier qui serait payant et jugé obligatoire. L'ouvrage Lehninger Principles of biochemistry est conseillé à titre facultatif pour un apprentissage plus approfondi
Faculty or entity
AGRO


Programmes / formations proposant cette unité d'enseignement (UE)

Title of the programme
Sigle
Credits
Prerequisites
Aims
Master [120] in Biomedical Engineering
GBIO2M
3
Bachelor in Bioengineering
BIR1BA
3
LBIR1250
Master [120] in Chemical and Materials Engineering
KIMA2M
3