Signalisation intercellulaire et biologie des tumeurs

WSBIM2141  2016-2017  Bruxelles Woluwe

Signalisation intercellulaire et biologie des tumeurs
3.0 credits
30.0 h
1q

Teacher(s)
Constantinescu Stefan ; Lemaigre Frédéric (coordinator) ; Feron Olivier ; Decottignies Anabelle ; Sonveaux Pierre ;
Language
Français
Prerequisites

fundamental principles in cell and molecular biology, and in biochemistry (metabolism) taught during the baccalaureate.

Main themes

The course describes the molecular and cell biology of intercellular signaling in normal condition and cancer, the mode of action of anti-cancer drugs, the interaction between tumor cells and their micro-environment, angiogenesis and metabolic anomalies resulting from the adaptation of tumor cells to their micro-environment (hypoxia and acidosis). The course will also address the issue of tumor cell immortality.

 

Aims

The course is expected to provide the students with the competence to:

- master the main intercellular signaling pathways, the interactions between tumor cells and blood vessels, the principles of cell immortality and the determinants of tumor cell metabolism;

- understand and explain how perturbed intercellular signaling, abnormal metabolism and cell immortality contribute to to tumor initiation and progression, and metastasis;

- understand and explain how anti-cancer drug modulate intercellular signaling;

- be able to design an experimental approach aiming at the identification of therapeutic targets;

- be able to critically address an oral presentation or article in the field;

- use the acquired knowledge to address knew issues.

 

The contribution of this Teaching Unit to the development and command of the skills and learning outcomes of the programme(s) can be accessed at the end of this sheet, in the section entitled “Programmes/courses offering this Teaching Unit”.

Content

 

 

Bibliography

The biology of Cancer, R.A. Weinberg, Garland Publishing

 

Other information

The course is taught in auditoria

Slides will be made available to the students.

Faculty or entity<


Programmes / formations proposant cette unité d'enseignement (UE)

Program title
Sigle
Credits
Prerequisites
Aims
Master [120] in Biomedicine
3
-

Master [60] in Biomedicine
3
-