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The student should be able to :
- Demonstrate his/her capacity to summarize and integrate various biochemical informations into a coherent set of knowledge
- Explain how a disease can result from abnormal gene expression
- Explain how molecular and metabolic anomalies lead to cancer
- Know the principles of glucose homeostasis
- Describe the regulation of synthesis and degradation of glucose, glycogen, ethanol, fructose and galactose, in health and disease
- Describe the structure and function of proteoglycans and glycoproteins
- Describe the regulation of synthesis and degradation of fatty acids, triglycerids, ketone bodies, and complex lipids, in health and disease
- Integrate hepatic, muscle, adipose and nervous metabolism in terms of metabolic fluxes in the fed and starved states
- Describe the regulation of synthesis and degradation of cholesterol and bile salts, in relation with gastrointestinal tract anatomy
- Describe the regulation of synthesis and degradation of plasma lipoproteins
- Know the principles of nitrogen and protein turnove, in health and disease
- Describe the key reactions of urea and aminoacid metabolism
- Describe purine and pyrimidine metabolism and understand how this interferes with drug metabolism
- Describe folic acid and Vitamin B12 metabolism, in relation with gastrointestinal tract anatomy
- Explain principles of abnormal oxygen transport by hemoglobin in disease
- Describe absorption, transport and storage of iron, in health and disease
- Describe syntesis and degradation of heme, in healthand disease and in relation with gastrointestinal tract anatomy
The contribution of this Teaching Unit to the development and
command of the skills and learning outcomes of the programme(s) can be
accessed at the end of this sheet, in the section entitled
“Programmes/courses offering this Teaching Unit”.
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