Génétique et épigénétique des tumeurs [ WSBIM2142 ]

Before taking this class, students must have followed molecular biology and genetic courses.

1. Cancer genetics: the goal of this chapter is to give an overview of the mechanism whereby the accumulation of DNA alteration give rise to cancer cells. We will define cancer cell clonality, oncogenes, tumor suppressors and cell selection and give specific examples.
2. Cancer epigenetics: this chapter focuses on the epigenetic alterations of cancer cells, including challenges and therapeutic opportunities.
3. Cancer genomics: this chapter focuses on novel technologies to study and diagnose cancer, in particular genome and transcriptome sequencing.

After this course, students should:

-          Understand the genetic and epigenetic mechanisms of tumorigenesis.

-          Know the various types of DNA alterations and the methods that are available to study them.

-          Link cancer genetics with diagnosis, prognosis and treatment.

Understand scientific literature on this topic (books, articles, publications, methods)

Presentations are available at http://icampus.uclouvain.be/.