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The student should be able to :
- Demonstrate his/her capacity to summarize and integrate various biochemical informations into a coherent set of knowledge
- Explain how a disease can result from abnormal gene expression
- Explain how molecular and metabolic anomalies lead to cancer
- Know the principles of glucose homeostasis
- Describe the regulation of synthesis and degradation of glucose, glycogen, ethanol, fructose and galactose, in health and disease
- Describe the structure and function of proteoglycans and glycoproteins
- Describe the regulation of synthesis and degradation of fatty acids, triglycerids, ketone bodies, and complex lipids, in health and disease
- Integrate hepatic, muscle, adipose and nervous metabolism in terms of metabolic fluxes in the fed and starved states
- Describe the regulation of synthesis and degradation of cholesterol and bile salts, in relation with gastrointestinal tract anatomy
- Describe the regulation of synthesis and degradation of plasma lipoproteins
- Know the principles of nitrogen and protein turnove, in health and disease
- Describe the key reactions of urea and aminoacid metabolism
- Describe purine and pyrimidine metabolism and understand how this interferes with drug metabolism
- Describe folic acid and Vitamin B12 metabolism, in relation with gastrointestinal tract anatomy
- Explain principles of abnormal oxygen transport by hemoglobin in disease
- Describe absorption, transport and storage of iron, in health and disease
- Describe syntesis and degradation of heme, in healthand disease and in relation with gastrointestinal tract anatomy
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