The molecular aspect of drugs [ WFARM1004 ]
2.0 crédits ECTS
15.0 h + 15.0 h
2q
| Teacher(s) |
Poupaert Jacques ;
Ayadim Mohamed ;
Frédérick Raphaël (coordinator) ;
|
| Language |
French
|
Place
of the course |
Bruxelles Woluwe
|
| Main themes |
The main themes of this course are :
(i) Molecular formulas, molecular mass, doses, dilutions.
(ii) Structural formulas of drugs : organic functions, isomerism, stereoisomerism, acid-base properties, water solubility, partition coefficient.
(iii) Biopharmaceuticals : peptides and carbohydrates.
(iv) Basic chemical reactivity of drugs and prodrugs.
|
| Aims |
Application of the logic of general and organic chemistry to commercial drugs and pharmaceutical preparations.
|
| Content |
The activity is a tutoring aimed to familiarize the students with the molecular structures and the structure-properties relationships of the medicinal specialities of the belgian market. The developed themes are : the structure, chemical functions, isomery and stereoisomery of the specialities in question, their acid-base properties in relation with their solubilities and hydrophobicity (link between molecular structure and log P), a first contact with active peptides, peptidomimetics and glycoconjugates, worked examples of the reaction of key functions with water as a function of pH.
|
| Other information |
Prerequisites :
Sufficient knowledge of French.
(i) when starting : having followed the MD1003 course "Chimie générale et minerale".
(ii) during the 2nd semester : following in parallel the MD1004 course "Chimie organique".
Evaluation : written examination measuring problem solving capabilities.
|
Cycle et année
d'étude |
> Bachelor in Pharmacy
|
Faculty or entity
in charge |
> FARM
|
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