Compléments de pharmacocinétique [ WFARM1339 ]

Pré-requis: WFARM1300

After having exposed the principles of drug chronic administration and covered all relative basic pharmacokinetic aspects, the effect of most common physiological (genetic, predisposition, environment,') and/or pathological (renal and hepatic failure) conditions on the different primary and secondary pharmacokinetic parameters and their potential consequences will be discussed. The influence of age (childhood and elderly) as well as over- and under-exposure on the pharmacokinetic behavior and the associated therapeutic response of several critical drugs will be developed.

The aim of this course is to demonstrate the clinical relevance of fine-tuning and optimizing some particular critical posology's and treatments in order to improve the therapeutic response in each individual. As a future pharmacist and drug specialist, it appears as fundamental that students understand that a substantial number of pathological situations (age, renal/hepatic failure, drug interactions,') and/or physiological and metabolic conditions (genetics, environment,') can deeply affect the fate of a drug in the body. 

-          Drug chronic administration

-          Renal insufficiency

-          Hepatic insufficiency

-          Influence of age and/or development

-          Drug interaction

-          Genetic predisposition

-          Influence of environmental factors

-          '

Support : Slides Power point