General introduction: ionizing radiations, concepts of radiobiology.
Reminder of cellular and molecular biology: the genome, the cellular cycle, the intracellular communication.
Effect of ionizing radiations on the integrity of the genome: spectrum and distribution of the lesions, mechanisms of repair.
Ionizing radiations and apoptose: implication in carcinogenesis and therapy.
Syndromes of hyper-sensitivity to ionizing radiations: implication in carcinogenesis and therapy. Biological dosimetry: techniques, utility and limitation