UCL - medical molecular genetics

[GEMO2110]

[30h] 2 credits

This course is taught in the 1st semester.

Teacher(s): Winnie COURTENS(coord.), Karin Dahan, Christine Dumoulin, Hélène Poirel, Catherine SIBILLE

Language: French

Level: Second

Aims
Main themes
Content and teaching methods
Other information (prerequisite, evaluation (assessment methods), course materials recommended readings, ...)

Aims

Illustrate the impact of molecular biology on our understanding of hereditary and acquired human diseases. Technical aspects are left out, as they are dealt with in other courses.

Main themes

1. Basic concepts reminder: the eukaryotic genome and the regulation of gene expression.
2. Methodological concepts : principles of genotypic analyses, restriction polymorphisms, mapping the human genome, inverse genetics, genotypic diagnostics.
3. Molecular biology and diseases. Molecular genetics of a few constitutive diseases, diseases caused by exogenous DNA, filiation analysis through molecular pedigree, gene therapy, industrial molecular biology.

Content and teaching methods

1. Basis concepts.
2. Methods.
3. Molecular genetics of some constitutive diseases.
4. Diseases caused by exogenous DNA.
5. Molecular pedigree.
6. Gene therapy.
7. Industrial molecular biology

Other information (prerequisite, evaluation (assessment methods), course materials recommended readings, ...)

Lecturing.
Evaluation through either a personal essay on one of the topics included in the lectures, or a conventional written examination.