UCL - Utilisation des radioisotopes et des molécules marquées en biologie

[RPR2330]

[15h + 15h] 3 credits

Teacher(s): Bernard Gallez(coord.), Thierry Vander Borght

Language: French

Level: Second

Aims
Main themes

Aims

Answer to three fundamental questions : why and how to use a radioactive isotope, and how to prepare it ?

Main themes

Introduction to the use of radioisotopes : tracer, applications in vitro (pharmacology, RIA) and in vivo (with comparison to other imaging modalities)
Preparation of radiolabelled molecules : nuclear reactions (neutron activation, charged particles, fission, generators), radiochemistry
Two examples illustrated from the nuclear reaction, radiochemistry, pharmaceutical conditioning, quality controls, and use in nuclear medicine (+ comparison/integration of other modalities for the diagnosis assessment) :
- 99mTc generator, diphosphonate kits for the use in bone scintigraphy
- 18F-fluorodeoxyglucose and applications in PET oncology