UCL - Pharmacokinetics and clinical biology

[FARM2140]

[30h + 15h] 4 credits

Teacher(s): Roger-K. Verbeeck, Pierre Wallemacq(coord.)

Language: French

Level: Second

Aims
Main themes
Content and teaching methods
Other information (prerequisite, evaluation (assessment methods), course materials recommended readings, ...)

Aims

The purpose of this lecture is to demonstrate and emphasized the clinical interest in optimizing some therapeutics. It is crucial for future health specialists to be aware that number of physiopathological situations may influence drug disposition (age, renal or hepatic insufficiency, drug interactions,). The lecture will demonstrate that both pharmacokinetics and therapeutic drug monitoring are necessary in this approach.

Main themes

Chronic administration, different dosage regimen, pathologies (renal or hepatic), age (children or elderly) and overdosing (toxicokinetics) will be discussed regarding the pharmacokinetics modifications involved. The different mechanisms causing drug interactions will be reviewed. Major analytical methods used in therapeutic drug monitoring including some pitfalls are described, together with the main pharmacological classes taking advantage of therapeutic drug monitoring (aminoglycosides, immunosuppressive drugs, antiepileptics, cardiotonics,).

Content and teaching methods

The method is based on a 30h academic lecture. Chronic administration, different dosage regimen, pathologies (renal or hepatic), age (children or elderly) and overdosing (toxicokinetics) will be discussed regarding the pharmacokinetics modifications involved. The different mechanisms causing drug interactions will be reviewed. Major analytical methods used in therapeutic drug monitoring including some pitfalls are described, together with the main pharmacological classes taking advantage of therapeutic drug monitoring (aminoglycosides, immunosuppressive drugs, antiepileptics, cardiotonics,).

Other information (prerequisite, evaluation (assessment methods), course materials recommended readings, ...)

Pre-requisite: lecture of general pharmacology including pharmacokinetics, drug metabolism, clinical biochemistry and general pathology.
Evaluation: written exam
Lectures are given with power-point slides shows accessible through the website iCampus