New aspects on the use of autoimmune serology
[BICL2104]
[15h] 2 credits
Teacher(s): Jean-Paul TOMASI
Language: French
Level: Second
Aims
Main themes
the course of patients with autoimmune diseases.
The first module addresses to the theoretical basis of autoimmunity and explores the basic mechanisms that might lead to a breakdown in tolerance and to autoimmune disease.
The second module looks at the interpretation of diagnostic tests in systemic autoimmune diseases. Diseases studied include rheumatoid arthritis SLE, Sjogren's syndrome, polymyositis scleroderma and vasculitis. Serological assays include rheumatoid factor, anti-cyclic citrullinated peptide, anti-nuclear antibody (ANA), anti-DNA antibody, anti-mitochondrial antibody (AMA), anti-smooth muscle antibody (ASMA), anti-Smith (Sm), anti-RNP, SSA, SSB, SCL70, Jo-1, anti-neutrophil cytoplasmic antibody, MPO and PR3.
The third module focusses on organ-specific autoimmunity. Several diseases are then studied, looking at their immunodiagnosis. These diseases includes autoimmune skin blistering diseases, autoimmune liver diseases, Menière's disease and autoimmune gut disease.
The final module looks at recent innovations concerning the use of analyser to test for common autoantibodies.
Content and teaching methods
Other information (prerequisite, evaluation (assessment methods), course materials recommended readings, ...)