UCL - Further Development in Clinical Chemistry

[BICL2100]

[60h] 6 credits

Teacher(s): Vincent Haufroid, Marianne Philippe, Pierre Wallemacq(coord.)

Language: French

Level: Second

Aims
Main themes
Content and teaching methods
Other information (prerequisite, evaluation (assessment methods), course materials recommended readings, ...)

Aims

Provide students information regarding pre-analytics, analytics and post-analytics phases in clinical chemistry, in an environment of quality assurance. At the end of the session, the future clinical chemist should possess the basis to become a privilege consultant interpreting laboratory results in different pathologies. Pratical aspects will be further illustrated in the lecture BICL2108 Séminaires de Biochimie Médicale et prélèvements sanguins

Main themes

Preanalytics
Analytical methods
Quality controls
Clinical enzymology
List of the major biochemical biomarkers (liver, kidney, cardiac, pancreatic functions, lipids, cystic fibrosis, etc)
Clinical interpretation

Content and teaching methods

The first part of the lecture will review all required preanalytical conditions (blood sampling, stability,). The second part will include assessment of analytical performances (reproducibility, sensitivity, specificity, ROC curve,). Among general topics, there will be clinical enzymology, Westgard rules, basis of automation, Among specific topics: oligoelements, porphyrias, urinanalysis, lipids, proteins, blood gas, cystic fibrosis diagnostic, bone markers, tumor markers, cardiac markers, pancreatic markers, kidney, thyroid, liver... The third part will be dedicate to protocols and validations (hemoglobinopathies, protein electrophoresis, therapeutic drug monitoring,).

Other information (prerequisite, evaluation (assessment methods), course materials recommended readings, ...)

Evaluation : written exam
Support : slides available on I-campus