Etudes physicochimiques des formes pharmaceutiques
[FARM2505]
[20h + 10h] 3 credits
Teacher(s): Véronique Préat, Bernard Tilquin, Rita Vanbever(coord.)
Language: French
Level: Second
Aims
Main themes
1. Analysis of the solid state :
Polymorphism and drug activity
Cristallography and X rays in chemical analysis
Methods of powder analysis :
Particle size
Powder density
Pulmonary deposition of aerosols in vitro
Surface analysis by X-ray photoelectron spectroscopy
Differential scanning calorimetry
2. Analysis of solutions :
Automatic determination of solubility and turbidimetry
3. Analysis of disperse systems :
Liquid interfaces :
Measurement of surface tension
Langmuir balance
Measurement of a CMC
Measurement of the stability of an emulsion
Inclusion complexes
Solid interfaces :
Wetting of solids and measurement of the contact angle
Measurement of the Zeta potential
Solid dispersions
Content and teaching methods
Theoretical course completed with an experimental work : measurement of solid cristallinity, measurement of particle size, measurement of powder density, measurement of the pulmonary deposition of aerosols in vitro, measurement of the Zeta potential.
Other information (prerequisite, evaluation (assessment methods), course materials recommended readings, ...)
Evaluation :
Oral or written examen (to be determined with the students), evaluation of the experimental work